UniProt P20936
Ras GTPase-activating protein 1 (P20936)
Ras GTPase-activating protein 1 (UniProt P20936): 23 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P20936
- Protein
- Ras GTPase-activating protein 1
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 16 · 2 records with a druggable one
Structures
24 records of P20936 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WER | RAS-GTPase-activating domain of human P120GAP | x-ray diffraction | A | — | — |
| 1WER | RAS-GTPase-activating domain of human P120GAP | x-ray diffraction | A | — | — |
| 1WQ1 | RAS-rasgap complex | x-ray diffraction | G | — | — |
| 1WQ1 | RAS-rasgap complex | x-ray diffraction | G | — | — |
| 2GQI | Solution structure of the SH3 domain of human Ras GTPase-activating protein 1 | solution nmr | A | — | — |
| 2GQI | Solution structure of the SH3 domain of human RAS GTPase-activating protein 1 | solution nmr | A | — | — |
| 2GSB | Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 | solution nmr | A | — | — |
| 2GSB | Solution structure of the second SH2 domain of human RAS GTPase- activating protein 1 | solution nmr | A | — | — |
| 2J05 | Crystal structure of the RasGAP SH3 domain at 1.5 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 2J05 | Crystal structure of the rasgap SH3 domain at 1.5 ångström resolution | x-ray diffraction | A, B | — | — |
| 2J06 | Crystal structure of the RasGAP SH3 domain at 1.8 Angstrom resolution | x-ray diffraction | A, B | — | — |
| 2J06 | Crystal structure of the rasgap SH3 domain at 1.8 ångström resolution | x-ray diffraction | A, B | — | — |
| 2M51 | NMR structure of the SH3 domain of human RAS p21 protein activator (GTPase activating protein) 1 | solution nmr | A | — | — |
| 2M51 | NMR structure of the SH3 domain of human RAS P21 protein activator (GTPase activating protein) 1 | solution nmr | A | — | — |
| 4FSS | Crystal structure of a RAS p21 protein activator (RASA1) from Homo sapiens at 2.25 A resolution | x-ray diffraction | A, B, C | — | — |
| 4FSS | Crystal structure of a RAS P21 protein activator (RASA1) from homo sapiens at 2.25 a resolution | x-ray diffraction | A, B, C | — | — |
| 6PXB | N-terminal SH2 domain of the P120RASGAP | x-ray diffraction | F, C, A, D, E, B | — | — |
| 6PXC | N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide | x-ray diffraction | A | — | — |
| 6PXC | N-terminal SH2 domain of the P120RASGAP bound to a P190RHOGAP phosphotyrosine peptide | x-ray diffraction | A | — | — |
| 6WAX | C-terminal SH2 domain of p120RasGAP | x-ray diffraction | A, B | SO4 | 2 (best 0.46) |
| 6WAX | C-terminal SH2 domain of P120RASGAP | x-ray diffraction | A, B | SO4 | — |
| 6WAY | C-terminal SH2 domain of P120RASGAP in complex with P190RHOGAP phosphotyrosine peptide | x-ray diffraction | A | — | — |
| 8BOS | Transition state analogue complex of small G protein and its GAP effector | x-ray diffraction | G | GDP, MGF, GAI | 2 (best 0.76) |
| P20936 | AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein 1 (P20936) | predicted | A | — | 12 (best 0.79) |
Ligands
Experiment against prediction
- 1WER chain A against the predicted model P20936: TM-score 0.99, RMSD 0.87 Å
- 1WER chain A against the predicted model P20936: TM-score 0.99, RMSD 0.87 Å
- 1WQ1 chain G against the predicted model P20936: TM-score 0.98, RMSD 1.10 Å
- 1WQ1 chain G against the predicted model P20936: TM-score 0.98, RMSD 1.10 Å
- 8BOS chain G against the predicted model P20936: TM-score 0.97, RMSD 1.10 Å
- 2J06 chain B against the predicted model P20936: TM-score 0.97, RMSD 0.90 Å
- 2J06 chain B against the predicted model P20936: TM-score 0.97, RMSD 0.90 Å
- 6PXC chain A against the predicted model P20936: TM-score 0.96, RMSD 0.79 Å
- 6PXC chain A against the predicted model P20936: TM-score 0.96, RMSD 0.79 Å
- 6WAY chain A against the predicted model P20936: TM-score 0.96, RMSD 0.92 Å
Elsewhere
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