MolNFT v1 · #332761 · protein
AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein 1 (P20936)
P20936: “AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein 1 (P20936)”. 12 pockets (best druggability 0.79). MolNFT v1 #332761 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P20936
- Type
- protein
- Length
- 1,047 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3298b100681D3A2372Bba3b2f282750dD71629B9
- Molecule
- RAS GTPase-activating protein 1
- UniProt
- P20936
- Pockets
- 12 · best druggability 0.79
Structure
1 distinct chain · 30% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS GTPase-activating protein 1 | protein | 1047 | 30% helix, 20% strand | P20936 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 986 | 0.79 | 0.80 | 80 | empty |
| 2 | 677 | 0.70 | 0.78 | 70 | empty |
| 3 | 605 | 0.64 | 0.75 | 60 | empty |
| 4 | 273 | 0.55 | 0.76 | 32 | empty |
| 5 | 213 | 0.51 | 0.76 | 30 | empty |
Compared structures
- 1WER · RAS-GTPase-activating domain of human P120GAP · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 1WER · RAS-GTPase-activating domain of human P120GAP · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 1WQ1 · RAS-rasgap complex · an experimental structure of the same protein · chain A against G, TM-score 0.30
- 1WQ1 · RAS-rasgap complex · an experimental structure of the same protein · chain A against G, TM-score 0.30
- 8BOS · Transition state analogue complex of small G protein and its GAP effector · an experimental structure of the same protein · chain A against G, TM-score 0.30
- 8DGQ · Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 2GSB · Solution structure of the second SH2 domain of human RAS GTPase- activating protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 2GSB · Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1 · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 6WAY · C-terminal SH2 domain of P120RASGAP in complex with P190RHOGAP phosphotyrosine peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 6WAY · C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide · an experimental structure of the same protein · chain A against A, TM-score 0.10
- 6WAX · C-terminal SH2 domain of p120RasGAP · an experimental structure of the same protein · chain A against A, TM-score 0.10
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20936
- Elsewhere: UniProt P20936 · AlphaFold DB P20936
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