C-terminal SH2 domain of P120RASGAP in complex with P190RHOGAP phosphotyrosine peptide

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 25% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains V
• NH2 · Amino group · ion · chains V

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–V · 557 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 6WAY · C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide · the same entry in another collection · chain A against A, TM-score 1.00
• P20936 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein 1 (P20936) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q9NRY4 · AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 35 (Q9NRY4) · a predicted model of the same protein · chain V against A, TM-score 0.68

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P20936
• Every structure of UniProt Q9NRY4
• Elsewhere: RCSB PDB 6WAY · PDBe 6WAY · UniProt P20936 · UniProt Q9NRY4