UniProt Q9NRY4
Rho GTPase-activating protein 35 (Q9NRY4)
Rho GTPase-activating protein 35 (UniProt Q9NRY4): 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NRY4
- Protein
- Rho GTPase-activating protein 35
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 2 records with a druggable one
Structures
10 records of Q9NRY4 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K85 | p190-A RhoGAP FF1 domain | solution nmr | A | — | — |
| 2K85 | P190-a rhogap FF1 domain | solution nmr | A | — | — |
| 3C5H | Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP) | x-ray diffraction | A | — | — |
| 3C5H | Crystal structure of the RAS homolog domain of human GRLF1 (P190RHOGAP) | x-ray diffraction | A | — | — |
| 3FK2 | Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1 | x-ray diffraction | A, B, C, D | — | — |
| 3FK2 | Crystal structure of the rhogap domain of human glucocorticoid receptor DNA-binding factor 1 | x-ray diffraction | A, B, C, D | — | — |
| 6WAY | C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide | x-ray diffraction | V | — | — |
| 6WAY | C-terminal SH2 domain of P120RASGAP in complex with P190RHOGAP phosphotyrosine peptide | x-ray diffraction | V | ACE, NH2 | — |
| 8DGQ | Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide | x-ray diffraction | U, V | — | 2 (best 0.74) |
| Q9NRY4 | AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 35 (Q9NRY4) | predicted | A | — | 16 (best 0.63) |
Ligands
Experiment against prediction
- 3FK2 chain A against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.80 Å
- 3FK2 chain A against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.80 Å
- 3FK2 chain B against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.66 Å
- 3FK2 chain B against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.66 Å
- 3FK2 chain C against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.86 Å
- 3FK2 chain C against the predicted model Q9NRY4: TM-score 0.98, RMSD 0.86 Å
- 3C5H chain A against the predicted model Q9NRY4: TM-score 0.97, RMSD 0.90 Å
- 3C5H chain A against the predicted model Q9NRY4: TM-score 0.97, RMSD 0.90 Å
- 2K85 chain A against the predicted model Q9NRY4: TM-score 0.89, RMSD 1.20 Å
- 2K85 chain A against the predicted model Q9NRY4: TM-score 0.89, RMSD 1.20 Å
Elsewhere
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