UniProt P19492
Glutamate receptor 3 (P19492)
Glutamate receptor 3 (UniProt P19492): 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P19492
- Protein
- Glutamate receptor 3
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 22 · 2 records with a druggable one
Structures
51 records of P19492 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3DLN | Crystal structure of the binding domain of the AMPA subunit GluR3 bound to glutamate | x-ray diffraction | A | — | — |
| 3DLN | Crystal structure of the binding domain of the AMPA subunit GLUR3 bound to glutamate | x-ray diffraction | A | — | — |
| 3DP4 | Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA | x-ray diffraction | A | — | — |
| 3DP4 | Crystal structure of the binding domain of the AMPA subunit GLUR3 bound to AMPA | x-ray diffraction | A | — | — |
| 3LSW | Aniracetam bound to the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 3LSW | Aniracetam bound to the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 3LSX | Piracetam bound to the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 3LSX | Piracetam bound to the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 3M3F | PEPA bound to the ligand binding domain of GluA3 (flop form) | x-ray diffraction | A | — | — |
| 3M3F | Pepa bound to the ligand binding domain of GLUA3 (flop form) | x-ray diffraction | A | — | — |
| 3M3K | Ligand binding domain (S1S2) of GluA3 (flop) | x-ray diffraction | A, C, E | — | — |
| 3M3K | Ligand binding domain (S1S2) of GLUA3 (flop) | x-ray diffraction | A, C, E | — | — |
| 3O21 | High resolution structure of GluA3 N-terminal domain (NTD) | x-ray diffraction | A, B, C, D | — | — |
| 3O21 | High resolution structure of GLUA3 N-terminal domain (ntd) | x-ray diffraction | A, B, C, D | — | — |
| 3P3W | Structure of a dimeric GluA3 N-terminal domain (NTD) at 4.2 A resolution | x-ray diffraction | A, B, C, D | — | — |
| 3P3W | Structure of a dimeric GLUA3 N-terminal domain (ntd) at 4.2 a resolution | x-ray diffraction | A, B, C, D | — | — |
| 3RT6 | Fluorowillardiine bound to the ligand binding domain of GluA3 | x-ray diffraction | B | — | — |
| 3RT6 | Fluorowillardiine bound to the ligand binding domain of GLUA3 | x-ray diffraction | B | — | — |
| 3RT8 | Chlorowillardiine bound to the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 3RT8 | Chlorowillardiine bound to the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F1Y | CNQX bound to the ligand binding domain of GluA3 | x-ray diffraction | A, C | — | — |
| 4F1Y | Cnqx bound to the ligand binding domain of GLUA3 | x-ray diffraction | A, C | — | — |
| 4F22 | Kainate bound to the K660A mutant of the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 4F22 | Kainate bound to the K660A mutant of the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F29 | Quisqualate bound to the ligand binding domain of GluA3i | x-ray diffraction | A | — | — |
| 4F29 | Quisqualate bound to the ligand binding domain of GLUA3I | x-ray diffraction | A | — | — |
| 4F2O | Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 4F2O | Quisqualate bound to the D655A mutant of the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F2Q | Quisqualate bound to the D655A mutant of the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 4F2Q | Quisqualate bound to the D655A mutant of the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F31 | Kainate bound to the D655A mutant of the ligand binding domain of GluA3 | x-ray diffraction | B, D | — | — |
| 4F31 | Kainate bound to the D655A mutant of the ligand binding domain of GLUA3 | x-ray diffraction | B, D | — | — |
| 4F39 | Kainate bound to the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 4F39 | Kainate bound to the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F3B | Glutamate bound to the D655A mutant of the ligand binding domain of GluA3 | x-ray diffraction | A | — | — |
| 4F3B | Glutamate bound to the D655A mutant of the ligand binding domain of GLUA3 | x-ray diffraction | A | — | — |
| 4F3G | Kainate bound to the ligand binding domain of GluA3i | x-ray diffraction | A | — | — |
| 4F3G | Kainate bound to the ligand binding domain of GLUA3I | x-ray diffraction | A | — | — |
| 5FWY | Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer | x-ray diffraction | B, D | NAG, SO4 | — |
| 5FWY | Crystal structure of the AMPA receptor GLUA2/A3 N-terminal domain heterodimer | x-ray diffraction | B, D | — | — |
| 5IDE | Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I) | electron microscopy | B, D | — | — |
| 5IDE | Cryo-EM structure of GLUA2/3 AMPA receptor heterotetramer (model I) | electron microscopy | B, D | — | — |
| 5IDF | Cryo-EM structure of GLUA2/3 AMPA receptor heterotetramer (model II) | electron microscopy | B, D | — | — |
| 6FLR | Super-open structure of the AMPAR GluA3 N-terminal domain | x-ray diffraction | A, B | NAG | 11 (best 0.64) |
| 6FLR | Super-open structure of the ampar GLUA3 N-terminal domain | x-ray diffraction | A, B | NAG | — |
| 6FPJ | Structure of the AMPAR GluA3 N-terminal domain bound to phosphate | x-ray diffraction | A, B, C | NAG, PO4 | — |
| 6FPJ | Structure of the ampar GLUA3 N-terminal domain bound to phosphate | x-ray diffraction | A, B, C | NAG, PO4 | — |
| 6NJM | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | A, C | NAG, ZK1 | 11 (best 0.86) |
| 6NJM | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | A, C | NAG, ZK1 | — |
| 6NJN | Architecture and subunit arrangement of native AMPA receptors | electron microscopy | C | NAG, ZK1 | — |
| P19492 | AlphaFold monomer V2.0 prediction for glutamate receptor 3 (P19492) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6FPJ chain C against the predicted model P19492: TM-score 0.98, RMSD 0.96 Å
- 6FPJ chain C against the predicted model P19492: TM-score 0.98, RMSD 0.96 Å
- 4F39 chain A against the predicted model P19492: TM-score 0.98, RMSD 0.76 Å
- 4F39 chain A against the predicted model P19492: TM-score 0.98, RMSD 0.76 Å
- 4F3G chain A against the predicted model P19492: TM-score 0.98, RMSD 0.81 Å
- 4F3G chain A against the predicted model P19492: TM-score 0.98, RMSD 0.81 Å
- 4F22 chain A against the predicted model P19492: TM-score 0.98, RMSD 0.81 Å
- 4F22 chain A against the predicted model P19492: TM-score 0.98, RMSD 0.81 Å
- 6FLR chain A against the predicted model P19492: TM-score 0.98, RMSD 1.04 Å
- 6FLR chain A against the predicted model P19492: TM-score 0.98, RMSD 1.04 Å
Elsewhere
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