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Ligand · PZI

PZI · 2-(2-oxopyrrolidin-1-yl)acetamide

PZI, 2-(2-oxopyrrolidin-1-yl)acetamide (C6 H10 N2 O2, 142.2 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
PZI
Formula
C6 H10 N2 O2
Class
ligand
Structures
6
PDB entries
3

Binding sites

PZI in 6 structures; the first of them:

  • 3LSF · Piracetam bound to the ligand binding domain of GluA2 · PZI B800 · binds TYR35, PRO105, PHE106, MET107, SER242, LEU247, ASP248, LYS251 and 1 more
  • 3LSL · Piracetam bound to the ligand binding domain of GluA2 (flop form) · PZI A800 · binds TYR35, PHE106, MET107, SER108, ASN242, LEU247, ASP248, LEU250 and 2 more
  • 3LSX · Piracetam bound to the ligand binding domain of GluA3 · PZI A802 · binds ASP248, ASN252
  • 3LSF · Piracetam bound to the ligand binding domain of GLUA2 · PZI B800 · binds TYR35, PRO105, PHE106, MET107, SER242, LEU247, ASP248, LYS251 and 1 more
  • 3LSL · Piracetam bound to the ligand binding domain of GLUA2 (flop form) · PZI A800 · binds TYR35, PHE106, MET107, SER108, ASN242, LEU247, ASP248, LEU250 and 2 more
  • 3LSX · Piracetam bound to the ligand binding domain of GLUA3 · PZI A802 · binds ASP248, ASN252

Residues it binds most

SER 26, ASN 26, ASP 26, LEU 22, LYS 18, MET 18, PHE 18, PRO 12, TYR 10, GLY 4 (residue and the binding sites it lines).

Found with

  • GLU · Glutamic acid
  • ZN · Zinc ion

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