MolNFT v1 · #70713 · protein
Piracetam bound to the ligand binding domain of GLUA2 (flop form)
3LSL · Glutamate receptor 2: “Piracetam bound to the ligand binding domain of GLUA2 (flop form)”. X-ray diffraction, 3 ligands (PZI, GLU, ZN), 6 pockets (best druggability 0.83). MolNFT v1 #70713 on GenesisL1: 3D structure, binding sites…
- PDB
- 3LSL
- Type
- protein
- Length
- 774 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- PZI, GLU, ZN
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G | Glutamate receptor 2 | protein | 258 | 38% helix, 21% strand | P19491 |
Ligands and binding sites
- PZI · 2-(2-oxopyrrolidin-1-yl)acetamide · ligand · 9 copies · chains A, D, G
- GLU · Glutamic acid · ligand · 3 copies · chains A, D, G
- ZN · Zinc ion · metal · 5 copies · chains A, D, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 976 | 0.83 | 0.84 | 123 | PZI |
| 2 | 266 | 0.58 | 0.78 | 29 | empty |
| 3 | 270 | 0.53 | 0.75 | 40 | empty |
| 4 | 92 | 0.41 | 0.78 | 24 | empty |
| 5 | 108 | 0.40 | 0.75 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–D · 983 Ų buried · 11 hydrogen bonds · protein-protein
- D–G · 294 Ų buried · 5 hydrogen bonds · protein-protein
- A–G · 79 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 3LSL · PDBe 3LSL · UniProt P19491
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