UniProt P19097
Fatty acid synthase subunit alpha (P19097)
Fatty acid synthase subunit alpha (UniProt P19097), EC 1.1.1.100, 2.3.1.41: 26 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 117 pockets. Binding sites, druggability and experiment against…
- UniProt
- P19097
- Protein
- Fatty acid synthase subunit alpha
- EC
- 1.1.1.100, 2.3.1.41, 2.3.1.86
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 117 · 9 records with a druggable one
Structures
27 records of P19097 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ML8 | NMR structure of Saccharomyces cerevisiae Acyl Carrier Protein. | solution nmr | A | — | — |
| 2ML8 | NMR structure of saccharomyces cerevisiae acyl carrier protein. | solution nmr | A | — | — |
| 2PFF | Structural Insights of Yeast Fatty Acid Synthase | x-ray diffraction | A, D, G | — | — |
| 2PFF | Structural insights of yeast fatty acid synthase | x-ray diffraction | A, D, G | — | — |
| 2UV8 | Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom… | x-ray diffraction | A, B, C | — | — |
| 2UV8 | Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 ångström… | x-ray diffraction | A, B, C | — | — |
| 2VKZ | Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex | x-ray diffraction | A, B, C | — | — |
| 2VKZ | Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex | x-ray diffraction | A, B, C | — | — |
| 2WAS | Structure of the fungal type I FAS PPT domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2WAS | Structure of the fungal type I fas ppt domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2WAT | Structure of the fungal type I FAS PPT domain in complex with CoA | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2WAT | Structure of the fungal type I fas ppt domain in complex with CoA | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3HMJ | Saccharomyces cerevisiae FAS type I | x-ray diffraction | A, B, C | — | — |
| 3HMJ | Saccharomyces cerevisiae fas type I | x-ray diffraction | A, B, C | — | — |
| 6JSH | Apo-state fatty acid synthase | electron microscopy | C, H, I | — | — |
| 6JSI | Co-purified fatty acid synthase | electron microscopy | C, H, I | — | — |
| 6TA1 | Fatty acid synthase of S. cerevisiae | electron microscopy | A, B, D, K, F, I | NDP | 16 (best 0.90) |
| 6WC7 | Acyl carrier protein (acp) domain bound to dehydratase (dh) domain in fungal fatty acid synthase… | electron microscopy | A | — | — |
| 8PRW | Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution | electron microscopy | A, B, C, D, E, F | NAP, COA | 14 (best 0.89) |
| 8PS1 | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | A, B | NAP, COA | 10 (best 0.77) |
| 8PS2 | Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam… | electron microscopy | A, B | A3Z, MLC | 12 (best 0.87) |
| 8PS8 | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | A, B | — | 14 (best 0.86) |
| 8PS9 | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | A, B | MLC | 11 (best 0.73) |
| 8PSA | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | A, B | — | 12 (best 0.73) |
| 8PSF | Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl… | electron microscopy | A, B | PNS | 16 (best 0.74) |
| 8PSK | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | A, B | — | 12 (best 0.71) |
| P19097 | AlphaFold monomer V2.0 prediction for fatty acid synthase subunit alpha (P19097) | predicted | A | — | — |
Ligands
- COA · Coenzyme A · in 2 records
- MLC · Malonyl-coenzyme A · in 2 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
- A3Z · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (~{E})-but-2-enethioate · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
- PNS · 4'-phosphopantetheine · in 1 record
Experiment against prediction
- 8PS2 chain B against the predicted model P19097: TM-score 0.99, RMSD 0.58 Å
- 8PS9 chain B against the predicted model P19097: TM-score 0.98, RMSD 0.61 Å
- 8PSK chain B against the predicted model P19097: TM-score 0.98, RMSD 0.62 Å
- 2WAS chain E against the predicted model P19097: TM-score 0.98, RMSD 0.52 Å
- 2WAS chain E against the predicted model P19097: TM-score 0.98, RMSD 0.52 Å
- 8PS1 chain B against the predicted model P19097: TM-score 0.98, RMSD 0.68 Å
- 2WAS chain D against the predicted model P19097: TM-score 0.98, RMSD 0.54 Å
- 2WAS chain D against the predicted model P19097: TM-score 0.98, RMSD 0.54 Å
- 8PSA chain B against the predicted model P19097: TM-score 0.98, RMSD 0.75 Å
- 2WAS chain F against the predicted model P19097: TM-score 0.98, RMSD 0.61 Å
Elsewhere
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