MolNFT v1 · #153860 · protein

Apo-state fatty acid synthase

6JSH · Fatty acid synthase subunit beta: “Apo-state fatty acid synthase”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #153860 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JSH
Type: protein
Length: 8,958 residues
Chains: 9
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid synthase subunit beta; Fatty acid synthase subunit alpha
UniProt: P19097
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 3 distinct chains · 30% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, F, G	Fatty acid synthase subunit beta	protein	1904	28% helix, 7% strand	—
A, D, E	Fatty acid synthase subunit alpha	protein	1011	32% helix, 5% strand	—
C, H, I	Fatty acid synthase subunit alpha	protein	71	54% helix, 0% strand	P19097

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1165	0.86	0.87	176	empty
2	1065	0.86	0.87	173	empty
3	505	0.83	0.89	100	empty
4	893	0.82	0.84	149	empty
5	215	0.81	0.94	30	empty

Interfaces

15 interfaces between chains.

A–F · 869 Å² buried · 11 hydrogen bonds · protein-protein
B–E · 864 Å² buried · 10 hydrogen bonds · protein-protein
D–G · 863 Å² buried · 10 hydrogen bonds · protein-protein
B–F · 703 Å² buried · 2 hydrogen bonds · protein-protein
B–G · 701 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6JSH · Apo-state Fatty Acid Synthase · the same entry in another collection · chain I against I, TM-score 1.00
P19097 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit alpha (P19097) · a predicted model of the same protein · chain C against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19097
Elsewhere: RCSB PDB 6JSH · PDBe 6JSH · UniProt P19097

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