MolNFT v1 · #153861 · protein

Co-purified fatty acid synthase

6JSI · Fatty acid synthase subunit beta: “Co-purified fatty acid synthase”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #153861 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JSI
Type: protein
Length: 9,888 residues
Chains: 9
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid synthase subunit beta; Fatty acid synthase subunit alpha
UniProt: P19097
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 3 distinct chains · 25% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, F, G	Fatty acid synthase subunit beta	protein	1904	24% helix, 6% strand	—
A, D, E	Fatty acid synthase subunit alpha	protein	1321	26% helix, 5% strand	—
C, H, I	Fatty acid synthase subunit alpha	protein	71	59% helix, 0% strand	P19097

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1181	0.85	0.87	191	empty
2	1029	0.84	0.85	126	empty
3	1029	0.82	0.84	123	empty
4	451	0.82	0.89	105	empty
5	1033	0.82	0.83	131	empty

Interfaces

15 interfaces between chains.

G–E · 1514 Å² buried · 10 hydrogen bonds · protein-protein
B–A · 1501 Å² buried · 11 hydrogen bonds · protein-protein
F–D · 1497 Å² buried · 11 hydrogen bonds · protein-protein
D–H · 1000 Å² buried · 9 hydrogen bonds · protein-protein
E–I · 998 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6JSI · Co-purified Fatty Acid Synthase · the same entry in another collection · chain I against I, TM-score 1.00
P19097 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit alpha (P19097) · a predicted model of the same protein · chain I against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19097
Elsewhere: RCSB PDB 6JSI · PDBe 6JSI · UniProt P19097

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