UniProt P18434
Potassium-transporting ATPase subunit beta (P18434)
Potassium-transporting ATPase subunit beta (UniProt P18434): 37 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P18434
- Protein
- Potassium-transporting ATPase subunit beta
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 36 · 5 records with a druggable one
Structures
38 records of P18434 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XZB | Pig Gastric H,K-ATPase with bound BeF and SCH28080 | electron crystallography | B | — | — |
| 2XZB | Pig gastric H,K-ATPase with bound bef and SCH28080 | electron crystallography | B | — | — |
| 2YN9 | Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium | electron crystallography | B | — | — |
| 2YN9 | Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium | electron crystallography | B | — | — |
| 3IXZ | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | electron crystallography | B | — | — |
| 3IXZ | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | electron crystallography | B | — | — |
| 4UX1 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. AlF) | electron crystallography | B | — | — |
| 4UX1 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2.ALF) | electron crystallography | B | — | — |
| 4UX2 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. MgF) | electron crystallography | B | — | — |
| 4UX2 | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2.MGF) | electron crystallography | B | — | — |
| 5Y0B | PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 | electron crystallography | B | — | 4 (best 0.79) |
| 5Y0B | Pig gastric H+,K+ - ATPase in complex with BYK99 | electron crystallography | B | — | — |
| 5YLU | Crystal structure of the gastric proton pump complexed with vonoprazan | x-ray diffraction | B | PCW, CE1, NAG | — |
| 5YLV | Crystal structure of the gastric proton pump complexed with SCH28080 | x-ray diffraction | B | CE1, NAG, PCW | — |
| 5YLV | Crystal structure of the gastric proton pump complexed with SCH28080 | x-ray diffraction | B | CE1, NAG, PCW | — |
| 6JXH | K+-bound E2-MgF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | B | PCW, CLR, NAG | — |
| 6JXH | K+-bound E2-mgf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | B | PCW, CLR, NAG | — |
| 6JXI | Rb+-bound E2-MgF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | B | PCW, NAG, CLR | — |
| 6JXI | Rb+-bound E2-mgf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | B | PCW, NAG, CLR | — |
| 6JXJ | Rb+-bound E2-AlF state of the gastric proton pump (Tyr799Trp) | x-ray diffraction | B | PCW, CLR, NAG, RB | — |
| 6JXJ | Rb+-bound E2-alf state of the gastric proton pump (TYR799TRP) | x-ray diffraction | B | PCW, CLR, NAG, RB | — |
| 6JXK | Rb+-bound E2-MgF state of the gastric proton pump (Wild-type) | x-ray diffraction | B, F | CLR, NAG | — |
| 6JXK | Rb+-bound E2-mgf state of the gastric proton pump (wild-type) | x-ray diffraction | B, F | CLR, NAG | — |
| 7EFL | Crystal structure of the gastric proton pump K791S in (BYK)E2BEF state | x-ray diffraction | B | NAG, RB | — |
| 7EFM | Crystal structure of the gastric proton pump K791S/E820D/Y340N in (BYK)E2BeF state | x-ray diffraction | B | NAG | 5 (best 0.71) |
| 7EFM | Crystal structure of the gastric proton pump K791S/E820D/Y340N in (BYK)E2BEF state | x-ray diffraction | B | NAG | — |
| 7EFN | Crystal structure of the gastric proton pump K791S/E820D/Y340N/E936V in (BYK)E2BEF state | x-ray diffraction | B | NAG | — |
| 7ET1 | Cryo-EM structure of the gastric proton pump K791S/E820D/Y340N/E936V/Y799W mutant in K+-occluded… | electron microscopy | B | CLR, PCW, NAG | — |
| 7W47 | Crystal structure of the gastric proton pump complexed with tegoprazan | x-ray diffraction | B | NAG | — |
| 7W48 | Crystal structure of the gastric proton pump complexed with pf- 03716556 | x-ray diffraction | B | CE1, NAG, PCW | — |
| 7W49 | Crystal structure of the gastric proton pump complexed with soraprazan | x-ray diffraction | B | NAG | 6 (best 0.45) |
| 7W49 | Crystal structure of the gastric proton pump complexed with soraprazan | x-ray diffraction | B | NAG | — |
| 7W4A | Cryo-EM structure of the gastric proton pump complexed with revaprazan | electron microscopy | B | NAG, PCW | 5 (best 0.48) |
| 7W4A | Cryo-EM structure of the gastric proton pump complexed with revaprazan | electron microscopy | B | NAG, PCW | — |
| 8IJV | Cryo-EM structure of the gastric proton pump with bound DQ-02 | electron microscopy | B | PCW, NAG, CLR | 6 (best 0.64) |
| 8JMN | Cryo-EM structure of the gastric proton pump with bound DQ-21 | electron microscopy | B | PCW, NAG, CLR | 5 (best 0.68) |
| 8WA5 | Cryo-EM structure of the gastric proton pump Y799W/E936Q mutant in K+-occluded (K+)E2-AlF state | electron microscopy | B | CLR, PCW, NAG | 5 (best 0.75) |
| P18434 | AlphaFold monomer V2.0 prediction for potassium-transporting ATPase subunit beta (P18434) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7W47 chain B against the predicted model P18434: TM-score 0.96, RMSD 1.42 Å
- 5YLU chain B against the predicted model P18434: TM-score 0.96, RMSD 1.49 Å
- 5YLV chain B against the predicted model P18434: TM-score 0.96, RMSD 1.46 Å
- 5YLV chain B against the predicted model P18434: TM-score 0.96, RMSD 1.46 Å
- 7W49 chain B against the predicted model P18434: TM-score 0.96, RMSD 1.46 Å
- 7W49 chain B against the predicted model P18434: TM-score 0.96, RMSD 1.46 Å
- 7EFL chain B against the predicted model P18434: TM-score 0.96, RMSD 1.44 Å
- 7EFN chain B against the predicted model P18434: TM-score 0.96, RMSD 1.48 Å
- 7W48 chain B against the predicted model P18434: TM-score 0.96, RMSD 1.50 Å
- 7ET1 chain B against the predicted model P18434: TM-score 0.96, RMSD 1.53 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.