MolNFT v1 · #177345 · protein

Crystal structure of the gastric proton pump K791S/E820D/Y340N/E936V in (BYK)E2BEF state

7EFN: “Crystal structure of the gastric proton pump K791S/E820D/Y340N/E936V in (BYK)E2BEF state”. X-ray diffraction, 4 ligands (J3C, NAG, RB). MolNFT v1 #177345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EFN
Type: protein
Length: 1,246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: A0A5G2QYH2, P18434
Ligands: J3C, NAG, RB, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	985	—	A0A5G2QYH2
B	—	protein	261	—	P18434

Ligands and binding sites

J3C · (7R,8R,9S)-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine-7,8-diol · ligand · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains B
RB · Rubidium ion · metal · 4 copies · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7EFN · Crystal structure of the gastric proton pump K791S/E820D/Y340N/E936V in (BYK)E2BeF state · the same entry in another collection · chain A against A, TM-score 1.00
P18434 · AlphaFold monomer V2.0 prediction for potassium-transporting ATPase subunit beta (P18434) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A5G2QYH2
Every structure of UniProt P18434
Elsewhere: RCSB PDB 7EFN · PDBe 7EFN · UniProt A0A5G2QYH2 · UniProt P18434

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