UniProt P16885
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (UniProt P16885), EC 3.1.4.11: 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 62 pockets. Binding sites, druggability and experiment…
- UniProt
- P16885
- Protein
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- EC
- 3.1.4.11
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 62 · 4 records with a druggable one
Structures
10 records of P16885 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K2J | NMR solution structure of the split PH domain from Phospholipase C gamma 2 | solution nmr | A | — | — |
| 2K2J | NMR solution structure of the split pH domain from phospholipase C gamma 2 | solution nmr | A | — | — |
| 2W2W | PLCg2 Split Pleckstrin Homology (PH) Domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2W2W | PLCG2 split pleckstrin homology (pH) domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2W2X | Complex of Rac2 and PLCg2 spPH Domain | x-ray diffraction | C, D | — | — |
| 2W2X | Complex of RAC2 and PLCG2 spph domain | x-ray diffraction | C, D | — | — |
| 8JQG | Cryo EM map of full length PLC gamma 2 | electron microscopy | A | — | 13 (best 0.75) |
| 8JQH | Cryo EM map of full length PLC gamma 2 in autoinhibition state | electron microscopy | A | — | 20 (best 0.73) |
| 8T7C | Crystal structure of human phospholipase C gamma 2 | x-ray diffraction | A | CA | 12 (best 0.80) |
| P16885 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase… | predicted | A | — | 17 (best 0.80) |
Ligands
- CA · Calcium ion · in 1 record
Experiment against prediction
- 8JQG chain A against the predicted model P16885: TM-score 0.97, RMSD 1.96 Å
- 2W2W chain I against the predicted model P16885: TM-score 0.97, RMSD 0.80 Å
- 2W2W chain I against the predicted model P16885: TM-score 0.97, RMSD 0.80 Å
- 2W2W chain L against the predicted model P16885: TM-score 0.97, RMSD 0.77 Å
- 2W2W chain L against the predicted model P16885: TM-score 0.97, RMSD 0.77 Å
- 2W2W chain J against the predicted model P16885: TM-score 0.96, RMSD 0.84 Å
- 2W2W chain J against the predicted model P16885: TM-score 0.96, RMSD 0.84 Å
- 2W2W chain H against the predicted model P16885: TM-score 0.95, RMSD 1.33 Å
- 2W2W chain H against the predicted model P16885: TM-score 0.95, RMSD 1.33 Å
- 2W2W chain G against the predicted model P16885: TM-score 0.95, RMSD 1.36 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.