MolNFT v1 · #52509 · protein
PLCG2 split pleckstrin homology (pH) domain
2W2W · 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase…: “PLCG2 split pleckstrin homology (pH) domain”. X-ray diffraction, 17 pockets (best druggability 0.72). MolNFT v1 #52509 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2W2W
- Type
- protein
- Length
- 1,186 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
- EC
- 3.1.4.11
- UniProt
- P16885
- Pockets
- 17 · best druggability 0.72
Structure
x-ray diffraction · 12 distinct chains · 17% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 108 | 20% helix, 44% strand | P16885 |
| B | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 108 | 14% helix, 44% strand | P16885 |
| C | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 105 | 17% helix, 45% strand | P16885 |
| D | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 99 | 15% helix, 46% strand | P16885 |
| E | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 101 | 18% helix, 46% strand | P16885 |
| F | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 107 | 17% helix, 44% strand | P16885 |
| G | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 101 | 18% helix, 46% strand | P16885 |
| H | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 94 | 16% helix, 47% strand | P16885 |
| I | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 97 | 15% helix, 46% strand | P16885 |
| J | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 94 | 16% helix, 49% strand | P16885 |
| K | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 98 | 18% helix, 45% strand | P16885 |
| L | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) | protein | 74 | 24% helix, 39% strand | P16885 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 661 | 0.72 | 0.79 | 68 | empty |
| 2 | 326 | 0.63 | 0.79 | 40 | empty |
| 3 | 405 | 0.60 | 0.76 | 54 | empty |
| 4 | 344 | 0.58 | 0.76 | 31 | empty |
| 5 | 346 | 0.57 | 0.76 | 30 | empty |
Interfaces
15 interfaces between chains.
- A–F · 802 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 723 Ų buried · 5 hydrogen bonds · protein-protein
- D–E · 586 Ų buried · 8 hydrogen bonds · protein-protein
- I–K · 529 Ų buried · 7 hydrogen bonds · protein-protein
- G–K · 451 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2W2W · PLCg2 Split Pleckstrin Homology (PH) Domain · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16885
- Elsewhere: RCSB PDB 2W2W · PDBe 2W2W · UniProt P16885
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