MolNFT v1 · #301056 · protein
AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (P16885)
P16885: “AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2…”. 17 pockets (best druggability 0.80). MolNFT v1 #301056 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P16885
- Type
- protein
- Length
- 1,265 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6C7844EE9CCb104C5dBBCcd588586c47744E0fFf
- Molecule
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- UniProt
- P16885
- Pockets
- 17 · best druggability 0.80
Structure
1 distinct chain · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | protein | 1265 | 34% helix, 27% strand | P16885 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 907 | 0.80 | 0.82 | 102 | empty |
| 2 | 970 | 0.75 | 0.78 | 70 | empty |
| 3 | 328 | 0.60 | 0.78 | 35 | empty |
| 4 | 151 | 0.59 | 0.83 | 27 | empty |
| 5 | 430 | 0.58 | 0.74 | 43 | empty |
Compared structures
- 8JQH · Cryo EM map of full length PLC gamma 2 in autoinhibition state · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 8JQI · Cryo EM map of full length PLC gamma 2 and FGFR1 Kinase Domain · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 8JQG · Cryo EM map of full length PLC gamma 2 · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 8T7C · Crystal structure of human phospholipase C gamma 2 · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 2K2J · NMR solution structure of the split pH domain from phospholipase C gamma 2 · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 2K2J · NMR solution structure of the split PH domain from Phospholipase C gamma 2 · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 2W2X · Complex of RAC2 and PLCG2 spph domain · an experimental structure of the same protein · chain A against C, TM-score 0.08
- 2W2X · Complex of Rac2 and PLCg2 spPH Domain · an experimental structure of the same protein · chain A against C, TM-score 0.08
- 2W2W · PLCg2 Split Pleckstrin Homology (PH) Domain · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 2W2W · PLCG2 split pleckstrin homology (pH) domain · an experimental structure of the same protein · chain A against A, TM-score 0.08
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16885
- Elsewhere: UniProt P16885 · AlphaFold DB P16885
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