UniProt P16615
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (UniProt P16615), EC 3.6.3.8, 7.2.2.10: 20 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 79 pockets. Binding sites, druggability and experiment…
- UniProt
- P16615
- Protein
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- EC
- 3.6.3.8, 7.2.2.10
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 79 · 5 records with a druggable one
Structures
21 records of P16615 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZTF | Structure of Ca2+ ATPase | x-ray diffraction | A | ACP, MG, CA | 16 (best 0.84) |
| 5ZTF | Structure of CA2+ ATPase | x-ray diffraction | A | ACP, MG, CA | — |
| 6JJU | Structure of CA2+ ATPase | x-ray diffraction | A | ACP, MG, CA | — |
| 6LLE | Cryoem structure of SERCA2B wt in E1-2CA2+-amppcp state. | electron microscopy | A | ACP, MG, CA | — |
| 6LLY | Cryoem structure of SERCA2B wt in E2-BEF3- state | electron microscopy | A | BEF, MG | — |
| 6LN5 | Cryoem structure of SERCA2B T1032STOP in E1-2CA2+-amppcp (CLASS1) | electron microscopy | A | ACP, MG, CA | — |
| 6LN6 | Cryoem structure of SERCA2B T1032STOP in E1-2CA2+-amppcp (CLASS2) | electron microscopy | A | ACP, MG, CA | — |
| 6LN7 | CryoEM structure of SERCA2b T1032stop in E1-2Ca2+-AMPPCP (class3) | electron microscopy | A | ACP, MG, CA | — |
| 6LN7 | Cryoem structure of SERCA2B T1032STOP in E1-2CA2+-amppcp (CLASS3) | electron microscopy | A | ACP, MG, CA | — |
| 6LN8 | CryoEM structure of SERCA2b T1032stop in E2-BeF3- state (class1) | electron microscopy | A | BEF, MG | — |
| 6LN8 | Cryoem structure of SERCA2B T1032STOP in E2-BEF3- state (CLASS1) | electron microscopy | A | BEF, MG | — |
| 6LN9 | CryoEM structure of SERCA2b T1032stop in E2-BeF3- state (class2) | electron microscopy | A | BEF, MG | — |
| 6LN9 | Cryoem structure of SERCA2B T1032STOP in E2-BEF3- state (CLASS2) | electron microscopy | A | BEF, MG | — |
| 7BT2 | Crystal structure of the SERCA2a in the E2.ATP state | x-ray diffraction | A | ATP, K, PCW | 16 (best 0.79) |
| 7BT2 | Crystal structure of the SERCA2A in the E2.ATP state | x-ray diffraction | A | ATP, K, PCW | — |
| 7E7S | Wt transporter STATE1 | electron microscopy | A | CA | — |
| 7W7T | The E1-BeF3- 2Ca2+ of SERCA2b | electron microscopy | A | CA, BEF, MG | 18 (best 0.82) |
| 7W7U | The 'Ca2+-unbound' BeF3- of SERCA2b | electron microscopy | A | BEF, MG | 17 (best 0.75) |
| 7W7V | 'late' E2P of SERCA2b | electron microscopy | A | BEF, MG | — |
| 7W7W | E2 Pi of SERCA2b | electron microscopy | A | ALF, MG | 12 (best 0.80) |
| P16615 | AlphaFold monomer V2.0 prediction for SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2 (P16615) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 17 records
- CA · Calcium ion · in 10 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 8 records
- BEF · Beryllium trifluoride ion · in 8 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- K · Potassium ion · in 2 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 2 records
- ALF · Tetrafluoroaluminate ion · in 1 record
Experiment against prediction
- 7W7W chain A against the predicted model P16615: TM-score 0.97, RMSD 1.93 Å
- 6LN9 chain A against the predicted model P16615: TM-score 0.94, RMSD 2.95 Å
- 6LN9 chain A against the predicted model P16615: TM-score 0.94, RMSD 2.95 Å
- 7W7V chain A against the predicted model P16615: TM-score 0.93, RMSD 3.10 Å
- 6LLY chain A against the predicted model P16615: TM-score 0.91, RMSD 3.44 Å
- 6LN8 chain A against the predicted model P16615: TM-score 0.91, RMSD 3.45 Å
- 6LN8 chain A against the predicted model P16615: TM-score 0.91, RMSD 3.45 Å
- 7W7U chain A against the predicted model P16615: TM-score 0.90, RMSD 3.60 Å
- 7E7S chain A against the predicted model P16615: TM-score 0.71, RMSD 5.72 Å
- 7BT2 chain A against the predicted model P16615: TM-score 0.69, RMSD 5.97 Å
Elsewhere
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