MolNFT v1 · #155892 · protein
Cryoem structure of SERCA2B wt in E2-BEF3- state
6LLY · SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2: “Cryoem structure of SERCA2B wt in E2-BEF3- state”. Electron microscopy, 2 ligands (BEF, MG), 17 pockets (best druggability 0.75). MolNFT v1 #155892 on GenesisL1: 3D structure…
- PDB
- 6LLY
- Type
- protein
- Length
- 1,006 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2
- EC
- 7.2.2.10
- UniProt
- P16615
- Ligands
- BEF, MG
- Pockets
- 17 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 49% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2 (EC 7.2.2.10) | protein | 1006 | 49% helix, 16% strand | P16615 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.75 | 0.86 | 45 | empty |
| 2 | 603 | 0.74 | 0.81 | 57 | empty |
| 3 | 394 | 0.67 | 0.80 | 58 | empty |
| 4 | 315 | 0.60 | 0.78 | 36 | empty |
| 5 | 362 | 0.59 | 0.75 | 32 | empty |
Compared structures
- 6LLY · CryoEM structure of SERCA2b WT in E2-BeF3- state · the same entry in another collection · chain A against A, TM-score 1.00
- P16615 · AlphaFold monomer V2.0 prediction for SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16615
- Elsewhere: RCSB PDB 6LLY · PDBe 6LLY · UniProt P16615
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