MolNFT v1 · #142110 · protein
Structure of CA2+ ATPase
5ZTF · SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2: “Structure of CA2+ ATPase”. X-ray diffraction, 3 ligands (ACP, CA, MG), 16 pockets (best druggability 0.84). MolNFT v1 #142110 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5ZTF
- Type
- protein
- Length
- 972 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2
- EC
- 3.6.3.8
- UniProt
- P16615
- Ligands
- ACP, CA, MG
- Pockets
- 16 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2 (EC 3.6.3.8) | protein | 972 | 49% helix, 17% strand | P16615 |
Ligands and binding sites
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1026 | 0.84 | 0.86 | 105 | ACP, MG |
| 2 | 84 | 0.69 | 0.93 | 22 | empty |
| 3 | 227 | 0.64 | 0.82 | 28 | empty |
| 4 | 381 | 0.61 | 0.77 | 40 | empty |
| 5 | 323 | 0.59 | 0.77 | 35 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16615
- Elsewhere: RCSB PDB 5ZTF · PDBe 5ZTF · UniProt P16615
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