UniProt P15919
V(D)J recombination-activating protein 1 (P15919)
V(D)J recombination-activating protein 1 (UniProt P15919), EC 2.3.2.27, 3.1.-.-: 50 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 812 pockets. Binding sites, druggability and experiment against…
- UniProt
- P15919
- Protein
- V(D)J recombination-activating protein 1
- EC
- 2.3.2.27, 3.1.-.-, 6.3.2.-
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 812 · 47 records with a druggable one
Structures
51 records of P15919 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RMD | RAG1 dimerization domain | x-ray diffraction | A | ZN | 1 (best 0.33) |
| 1RMD | RAG1 dimerization domain | x-ray diffraction | A | ZN | 1 (best 0.33) |
| 3GNA | Crystal structure of the RAG1 nonamer-binding domain with DNA | x-ray diffraction | A | — | 1 (best 0.51) |
| 3GNA | Crystal structure of the RAG1 nonamer-binding domain with DNA | x-ray diffraction | A | — | 1 (best 0.51) |
| 3GNB | Crystal structure of the RAG1 nonamer-binding domain with DNA | x-ray diffraction | A | — | 1 (best 0.47) |
| 3GNB | Crystal structure of the RAG1 nonamer-binding domain with DNA | x-ray diffraction | A | — | 1 (best 0.47) |
| 4WWX | Crystal structure of the core RAG1/2 recombinase | x-ray diffraction | B, E | ZN | 19 (best 0.82) |
| 4WWX | Crystal structure of the core RAG1/2 recombinase | x-ray diffraction | B, E | ZN | 19 (best 0.82) |
| 5ZDZ | Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in Ca2+ | x-ray diffraction | A, C | CA, ZN, K | 18 (best 0.83) |
| 5ZDZ | Hairpin forming complex, RAG1/2-nicked 12RSS/23RSS complex in CA2+ | x-ray diffraction | A, C | CA, ZN, K | 18 (best 0.83) |
| 5ZE0 | Hairpin Forming Complex, RAG1/2-Nicked(with Dideoxy) 12RSS/23RSS complex in Mg2+ | x-ray diffraction | A, C | MG, ZN, K | 18 (best 0.83) |
| 5ZE0 | Hairpin forming complex, RAG1/2-NICKED(WITH dideoxy) 12RSS/23RSS complex in MG2+ | x-ray diffraction | A, C | MG, ZN, K | 18 (best 0.83) |
| 5ZE1 | Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C | x-ray diffraction | A, C | ZN, MN, K | 18 (best 0.83) |
| 5ZE1 | Hairpin forming complex, RAG1/2-nicked 12RSS/23RSS complex in 2MM MN2+ for 10 min at 4'C | x-ray diffraction | A, C | ZN, MN, K | 18 (best 0.83) |
| 5ZE2 | Hairpin Complex, RAG1/2-hairpin 12RSS/23RSS complex in 5mM Mn2+ for 2 min at 4'C | x-ray diffraction | A, C | ZN, MN, K | 19 (best 0.83) |
| 5ZE2 | Hairpin complex, RAG1/2-hairpin 12RSS/23RSS complex in 5MM MN2+ for 2 min at 4'C | x-ray diffraction | A, C | ZN, MN, K | 19 (best 0.83) |
| 6CG0 | Cryo-EM structure of mouse RAG1/2 HFC complex (3.17 A) | electron microscopy | A, C | ZN, CA | 20 (best 0.88) |
| 6CG0 | Cryo-EM structure of mouse RAG1/2 hfc complex (3.17 a) | electron microscopy | A, C | ZN, CA | 20 (best 0.88) |
| 6CIJ | Cryo-EM structure of mouse RAG1/2 HFC complex containing partial HMGB1 linker(3.9 A) | electron microscopy | A, C | ZN, CA | 19 (best 0.86) |
| 6CIJ | Cryo-EM structure of mouse RAG1/2 hfc complex containing partial HMGB1 LINKER(3.9 a) | electron microscopy | A, C | ZN, CA | 19 (best 0.86) |
| 6CIK | Pre-Reaction Complex, RAG1(E962Q)/2-intact/nicked 12/23RSS complex in Mn2+ | x-ray diffraction | A, C | ZN, MN | 17 (best 0.86) |
| 6CIK | Pre-reaction complex, RAG1(E962Q)/2-INTACT/NICKED 12/23RSS complex in MN2+ | x-ray diffraction | A, C | ZN, MN | 17 (best 0.86) |
| 6CIL | Pre-reaction complex, RAG1(E962Q)/2-INTACT/INTACT 12/23RSS complex in MN2+ | x-ray diffraction | A, C | ZN, MN | 19 (best 0.86) |
| 6CIL | Pre-reaction complex, RAG1(E962Q)/2-INTACT/INTACT 12/23RSS complex in MN2+ | x-ray diffraction | A, C | ZN, MN | 19 (best 0.86) |
| 6CIM | Pre-Reaction Complex, RAG1(E962Q)/2-nicked/intact 12/23RSS complex in Mn2+ | x-ray diffraction | A, C | ZN, MN | 17 (best 0.86) |
| 6CIM | Pre-reaction complex, RAG1(E962Q)/2-NICKED/INTACT 12/23RSS complex in MN2+ | x-ray diffraction | A, C | ZN, MN | 17 (best 0.86) |
| 6OEM | Cryo-EM structure of mouse RAG1/2 PRC complex (DNA0) | electron microscopy | A, C | MG, ZN | 18 (best 0.84) |
| 6OEM | Cryo-EM structure of mouse RAG1/2 prc complex (DNA0) | electron microscopy | A, C | MG, ZN | 18 (best 0.84) |
| 6OEN | Cryo-EM structure of mouse RAG1/2 PRC complex (DNA1) | electron microscopy | A, C | ZN, CA | 19 (best 0.85) |
| 6OEN | Cryo-EM structure of mouse RAG1/2 prc complex (DNA1) | electron microscopy | A, C | ZN, CA | 19 (best 0.85) |
| 6OEO | Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1) | electron microscopy | A, C | CA, ZN | 15 (best 0.81) |
| 6OEO | Cryo-EM structure of mouse RAG1/2 nfc complex (DNA1) | electron microscopy | A, C | CA, ZN | 15 (best 0.81) |
| 6OEP | Cryo-EM structure of mouse RAG1/2 12RSS-NFC/23RSS-PRC complex (DNA1) | electron microscopy | A, C | CA, ZN | 18 (best 0.85) |
| 6OEP | Cryo-EM structure of mouse RAG1/2 12RSS-NFC/23RSS-prc complex (DNA1) | electron microscopy | A, C | CA, ZN | 18 (best 0.85) |
| 6OEQ | Cryo-EM structure of mouse RAG1/2 12RSS-PRC/23RSS-NFC complex (DNA1) | electron microscopy | A, C | ZN, CA | 17 (best 0.83) |
| 6OEQ | Cryo-EM structure of mouse RAG1/2 12RSS-PRC/23RSS-nfc complex (DNA1) | electron microscopy | A, C | ZN, CA | 17 (best 0.83) |
| 6OER | Cryo-EM structure of mouse RAG1/2 NFC complex (DNA2) | electron microscopy | A, C | ZN, CA | 18 (best 0.87) |
| 6OER | Cryo-EM structure of mouse RAG1/2 nfc complex (DNA2) | electron microscopy | A, C | ZN, CA | 18 (best 0.87) |
| 6OES | Cryo-EM structure of mouse RAG1/2 STC complex (without NBD domain) | electron microscopy | A, C | CA, ZN | 20 (best 0.87) |
| 6OES | Cryo-EM structure of mouse RAG1/2 stc complex (without nbd domain) | electron microscopy | A, C | CA, ZN | 20 (best 0.87) |
| 6OET | Cryo-EM structure of mouse RAG1/2 STC complex | electron microscopy | A, C | CA, ZN | 20 (best 0.82) |
| 6OET | Cryo-EM structure of mouse RAG1/2 stc complex | electron microscopy | A, C | CA, ZN | 20 (best 0.82) |
| 6V0V | Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0) | electron microscopy | A | CA, ZN | 13 (best 0.86) |
| 6V0V | Cryo-EM structure of mouse wt RAG1/2 nfc complex (DNA0) | electron microscopy | A | CA, ZN | 13 (best 0.86) |
| 6XNX | Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Dynamic-Form) | electron microscopy | A, C | MG, ZN | 19 (best 0.86) |
| 6XNX | Structure of RAG1 (R848M/E649V)-RAG2-DNA strand transfer complex (dynamic-form) | electron microscopy | A, C | MG, ZN | 19 (best 0.86) |
| 6XNY | Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Paired-Form) | electron microscopy | A, C | MG, ZN | 19 (best 0.88) |
| 6XNY | Structure of RAG1 (R848M/E649V)-RAG2-DNA strand transfer complex (paired-form) | electron microscopy | A, C | MG, ZN | 19 (best 0.88) |
| 6XNZ | Structure of RAG1 (R848M/E649V)-RAG2-DNA Target Capture Complex | electron microscopy | A, C | ZN | 20 (best 0.81) |
| 6XNZ | Structure of RAG1 (R848M/E649V)-RAG2-DNA target capture complex | electron microscopy | A, C | ZN | 20 (best 0.81) |
| P15919 | AlphaFold monomer V2.0 prediction for V(D)J recombination-activating protein 1 (P15919) | predicted | A | — | 6 (best 0.70) |
Ligands
Experiment against prediction
- 6OES chain A against the predicted model P15919: TM-score 0.99, RMSD 0.59 Å
- 6OES chain A against the predicted model P15919: TM-score 0.99, RMSD 0.59 Å
- 6OES chain C against the predicted model P15919: TM-score 0.99, RMSD 0.59 Å
- 6OES chain C against the predicted model P15919: TM-score 0.99, RMSD 0.59 Å
- 5ZE2 chain C against the predicted model P15919: TM-score 0.99, RMSD 0.73 Å
- 5ZE2 chain C against the predicted model P15919: TM-score 0.99, RMSD 0.73 Å
- 5ZE1 chain C against the predicted model P15919: TM-score 0.99, RMSD 0.74 Å
- 5ZE1 chain C against the predicted model P15919: TM-score 0.99, RMSD 0.74 Å
- 5ZDZ chain C against the predicted model P15919: TM-score 0.99, RMSD 0.75 Å
- 5ZDZ chain C against the predicted model P15919: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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