UniProt P15389
Sodium channel protein type 5 subunit alpha,Green fluorescent protein (P15389)
Sodium channel protein type 5 subunit alpha,Green fluorescent protein (UniProt P15389): 11 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 158 pockets. Binding sites, druggability and experiment…
- UniProt
- P15389
- Protein
- Sodium channel protein type 5 subunit alpha,Green fluorescent protein
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 158 · 8 records with a druggable one
Structures
12 records of P15389 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UZ0 | Cardiac sodium channel with flecainide | electron microscopy | A | NAG, 9Z9, 6OU, K4D | 20 (best 0.87) |
| 6UZ0 | Cardiac sodium channel with flecainide | electron microscopy | A | NAG, 9Z9, 6OU, K4D | — |
| 6UZ3 | Cardiac sodium channel | electron microscopy | A | NAG, 9Z9, 6OU | 20 (best 0.86) |
| 6UZ3 | Cardiac sodium channel | electron microscopy | A | NAG, 9Z9, 6OU | — |
| 7FBS | structure of a channel | electron microscopy | A | NAG, 6OU, 4Y4, 9Z9 | 20 (best 0.83) |
| 7FBS | Structure of a channel | electron microscopy | A | NAG, 6OU, 4Y4, 9Z9 | — |
| 7K18 | Cardiac Sodium channel with toxin bound | electron microscopy | A | NAG, 6OU | 19 (best 0.86) |
| 7K18 | Cardiac sodium channel with toxin bound | electron microscopy | A | NAG, 6OU | — |
| 7XSU | Cardiac sodium channel in complex with LqhIII | electron microscopy | A | NAG, 6OU, 9Z9 | 19 (best 0.83) |
| 8F6P | Rat Cardiac Sodium Channel with Ranolazine Bound | electron microscopy | A | NAG, BMA, XHO, 6OU, Y01 | 20 (best 0.86) |
| 8T6L | Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B | electron microscopy | A | NAG, BMA, MAN, LBN, Y01, 9Z9 | 20 (best 0.85) |
| P15389 | AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (P15389) | predicted | A | — | 20 (best 0.87) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 11 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 10 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 8 records
- 4Y4 · 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one · in 2 records
- BMA · beta-D-mannopyranose · in 2 records
- K4D · Flecainide · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- XHO · (R)-ranolazine · in 1 record
- YIJ · (1R)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-9,12-dihydroxy-2,11a-dimethyl-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-7H-9,11b-epoxy-13a,5a-prop[1]enophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl benzoate · in 1 record
Experiment against prediction
- 8F6P chain A against the predicted model P15389: TM-score 0.98, RMSD 1.69 Å
- 8T6L chain A against the predicted model P15389: TM-score 0.98, RMSD 1.83 Å
- 7FBS chain A against the predicted model P15389: TM-score 0.97, RMSD 1.85 Å
- 7FBS chain A against the predicted model P15389: TM-score 0.97, RMSD 1.85 Å
- 6UZ0 chain A against the predicted model P15389: TM-score 0.97, RMSD 1.99 Å
- 6UZ0 chain A against the predicted model P15389: TM-score 0.97, RMSD 1.99 Å
- 7XSU chain A against the predicted model P15389: TM-score 0.97, RMSD 1.82 Å
- 6UZ3 chain A against the predicted model P15389: TM-score 0.97, RMSD 2.05 Å
- 6UZ3 chain A against the predicted model P15389: TM-score 0.97, RMSD 2.05 Å
- 7K18 chain A against the predicted model P15389: TM-score 0.97, RMSD 1.87 Å
Elsewhere
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