MolNFT v1 · #421520 · protein
AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (P15389)
P15389: “AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (P15389)”. 20 pockets (best druggability 0.87). MolNFT v1 #421520 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P15389
- Type
- protein
- Length
- 2,019 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x54E712e282c590D9A20961451A63f1380e0a3dD4
- Molecule
- Sodium channel protein type 5 subunit alpha
- UniProt
- P15389
- Pockets
- 20 · best druggability 0.87
Structure
1 distinct chain · 53% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium channel protein type 5 subunit alpha | protein | 2019 | 53% helix, 3% strand | P15389 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1092 | 0.87 | 0.87 | 90 | empty |
| 2 | 1117 | 0.76 | 0.79 | 93 | empty |
| 3 | 605 | 0.72 | 0.80 | 58 | empty |
| 4 | 458 | 0.68 | 0.79 | 47 | empty |
| 5 | 373 | 0.63 | 0.78 | 35 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 8T6L · Cryo-EM structure of rat cardiac sodium channel NaV1.5 with batrachotoxin analog BTX-B · an experimental structure of the same protein · chain A against A, TM-score 0.60
- 6UZ0 · Cardiac sodium channel with flecainide · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 6UZ3 · Cardiac sodium channel · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 7K18 · Cardiac sodium channel with toxin bound · an experimental structure of the same protein · chain A against A, TM-score 0.55
- 7FBS · Structure of a channel · an experimental structure of the same protein · chain A against A, TM-score 0.54
- 7XSU · Cardiac sodium channel in complex with LqhIII · an experimental structure of the same protein · chain A against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15389
- Elsewhere: UniProt P15389 · AlphaFold DB P15389
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