UniProt P15145
Aminopeptidase N (P15145)
Aminopeptidase N (UniProt P15145), EC 3.4.11.2: 30 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15145
- Protein
- Aminopeptidase N
- EC
- 3.4.11.2
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 20 · 3 records with a druggable one
Structures
31 records of P15145 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4F5C | Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in… | x-ray diffraction | A, B | — | — |
| 4F5C | Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in… | x-ray diffraction | A, B | — | — |
| 4FKE | Crystal structure of porcine aminopeptidase-N | x-ray diffraction | A | — | — |
| 4FKE | Crystal structure of porcine aminopeptidase-N | x-ray diffraction | A | — | — |
| 4FKH | Crystal structure of porcine aminopeptidase-N complexed with alanine | x-ray diffraction | A | — | — |
| 4FKH | Crystal structure of porcine aminopeptidase-N complexed with alanine | x-ray diffraction | A | — | — |
| 4FKK | Crystal structure of porcine aminopeptidase-N complexed with bestatin | x-ray diffraction | A | — | — |
| 4FKK | Crystal structure of porcine aminopeptidase-N complexed with bestatin | x-ray diffraction | A | — | — |
| 4HOM | Crystal structure of porcine aminopeptidase-N complexed with substance P | x-ray diffraction | A | — | — |
| 4HOM | Crystal structure of porcine aminopeptidase-N complexed with substance P | x-ray diffraction | A | — | — |
| 4NAQ | Crystal structure of porcine aminopeptidase-N complexed with poly-alanine | x-ray diffraction | A | — | — |
| 4NAQ | Crystal structure of porcine aminopeptidase-N complexed with poly- alanine | x-ray diffraction | A | — | — |
| 4NZ8 | Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine | x-ray diffraction | A | — | — |
| 4NZ8 | Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine | x-ray diffraction | A | — | — |
| 4OU3 | Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide | x-ray diffraction | A | — | — |
| 4OU3 | Crystal structure of porcine aminopeptidase N complexed with cngrcg tumor-homing peptide | x-ray diffraction | A | — | — |
| 5LDS | Structure of the porcine aminopeptidase N ectodomain | x-ray diffraction | A, B, C, D | NAG, BMA, ZN | — |
| 5LDS | Structure of the porcine aminopeptidase N ectodomain | x-ray diffraction | A, B, C, D | NAG, BMA, ZN | — |
| 5LG6 | Structure of the deglycosylated porcine aminopeptidase N ectodomain | x-ray diffraction | A, B | NAG, ZN | — |
| 5LG6 | Structure of the deglycosylated porcine aminopeptidase N ectodomain | x-ray diffraction | A, B | NAG, ZN | — |
| 6BUY | Crystal structure of porcine aminopeptidase-N with Glycine | x-ray diffraction | A | NAG, GLY, SO4, ZN | 7 (best 0.63) |
| 6BUY | Crystal structure of porcine aminopeptidase-N with glycine | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV0 | Crystal structure of porcine aminopeptidase-N with Arginine | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV0 | Crystal structure of porcine aminopeptidase-N with arginine | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV1 | Crystal structure of porcine aminopeptidase-N with aspartic acid | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV2 | Crystal structure of porcine aminopeptidase-N with isoleucine | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV3 | Crystal structure of porcine aminopeptidase-N with Leucine | x-ray diffraction | A | NAG, LEU, SO4, ZN | 7 (best 0.64) |
| 6BV3 | Crystal structure of porcine aminopeptidase-N with leucine | x-ray diffraction | A | NAG, SO4, ZN | — |
| 6BV4 | Crystal structure of porcine aminopeptidase-N with Methionine | x-ray diffraction | A | NAG, MET, SO4, ZN | 6 (best 0.71) |
| 6BV4 | Crystal structure of porcine aminopeptidase-N with methionine | x-ray diffraction | A | NAG, SO4, ZN | — |
| P15145 | AlphaFold monomer V2.0 prediction for aminopeptidase N (P15145) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5LG6 chain B against the predicted model P15145: TM-score 0.99, RMSD 0.72 Å
- 5LG6 chain B against the predicted model P15145: TM-score 0.99, RMSD 0.72 Å
- 5LG6 chain A against the predicted model P15145: TM-score 0.99, RMSD 0.75 Å
- 5LG6 chain A against the predicted model P15145: TM-score 0.99, RMSD 0.75 Å
- 5LDS chain C against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
- 5LDS chain C against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
- 5LDS chain D against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
- 5LDS chain D against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
- 5LDS chain A against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
- 5LDS chain A against the predicted model P15145: TM-score 0.99, RMSD 0.76 Å
Elsewhere
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