UniProt P14618
Pyruvate kinase PKM (P14618)
Pyruvate kinase PKM (UniProt P14618), EC 2.7.1.40, 2.7.10.2: 91 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 309 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P14618
- Protein
- Pyruvate kinase PKM
- EC
- 2.7.1.40, 2.7.10.2, 2.7.11.1
- Experimental structures
- 91
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 309 · 16 records with a druggable one
Structures
92 records of P14618 in the MolNFT archive: 91 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T5A | Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 1T5A | Human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 1ZJH | Structure of human muscle pyruvate kinase (PKM2) | x-ray diffraction | A | — | — |
| 1ZJH | Structure of human muscle pyruvate kinase (PKM2) | x-ray diffraction | A | — | — |
| 3BJF | Pyruvate kinase M2 is a phosphotyrosine binding protein | x-ray diffraction | A, B, C, D | — | — |
| 3BJF | Pyruvate kinase M2 is a phosphotyrosine binding protein | x-ray diffraction | A, B, C, D | — | — |
| 3BJT | Pyruvate kinase M2 is a phosphotyrosine binding protein | x-ray diffraction | A, B, C, D | — | — |
| 3BJT | Pyruvate kinase M2 is a phosphotyrosine binding protein | x-ray diffraction | A, B, C, D | — | — |
| 3G2G | S437Y Mutant of human muscle pyruvate kinase, isoform M2 | x-ray diffraction | A, B, C, D | — | — |
| 3G2G | S437Y mutant of human muscle pyruvate kinase, isoform M2 | x-ray diffraction | A, B, C, D | — | — |
| 3GQY | Activator-Bound Structure of Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3GQY | Activator-bound structure of human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3GR4 | Activator-Bound Structure of Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3GR4 | Activator-bound structure of human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3H6O | Activator-Bound Structure of Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3H6O | Activator-bound structure of human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3ME3 | Activator-Bound Structure of Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3ME3 | Activator-bound structure of human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3SRD | Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate. | x-ray diffraction | A, B, C, D | — | — |
| 3SRD | Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and oxalate. | x-ray diffraction | A, B, C, D | — | — |
| 3SRF | Human M1 pyruvate kinase | x-ray diffraction | C, A, B, D, E, F, G, H | — | — |
| 3SRF | Human M1 pyruvate kinase | x-ray diffraction | C, A, B, D, E, F, G, H | — | — |
| 3SRH | Human M2 pyruvate kinase | x-ray diffraction | A, B, C, D | — | — |
| 3SRH | Human M2 pyruvate kinase | x-ray diffraction | A, B, C, D | — | — |
| 3U2Z | Activator-Bound Structure of Human Pyruvate Kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 3U2Z | Activator-bound structure of human pyruvate kinase M2 | x-ray diffraction | A, B, C, D | — | — |
| 4B2D | human PKM2 with L-serine and FBP bound. | x-ray diffraction | A, B, C, D | — | — |
| 4B2D | Human PKM2 with L-serine and fbp bound. | x-ray diffraction | A, B, C, D | — | — |
| 4FXF | Structure of M2 pyruvate kinase in complex with phenylalanine | x-ray diffraction | A, D, C, B | — | — |
| 4FXF | Structure of M2 pyruvate kinase in complex with phenylalanine | x-ray diffraction | A, D, C, B | — | — |
| 4FXJ | Structure of M2 pyruvate kinase in complex with phenylalanine | x-ray diffraction | A, B, C, D | — | — |
| 4FXJ | Structure of M2 pyruvate kinase in complex with phenylalanine | x-ray diffraction | A, B, C, D | — | — |
| 4G1N | PKM2 in complex with an activator | x-ray diffraction | A, B, C, D | — | — |
| 4G1N | PKM2 in complex with an activator | x-ray diffraction | A, B, C, D | — | — |
| 4JPG | 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators | x-ray diffraction | A, B, C, D | — | — |
| 4JPG | 2-((1H-BENZO[D]IMIDAZOL-1-YL)METHYL)-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ones as novel PKM2 activators | x-ray diffraction | A, B, C, D | — | — |
| 4QG6 | crystal structure of PKM2-Y105E mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QG6 | Crystal structure of PKM2-Y105E mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QG8 | crystal structure of PKM2-K305Q mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QG8 | Crystal structure of PKM2-K305Q mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QG9 | crystal structure of PKM2-R399E mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QG9 | Crystal structure of PKM2-R399E mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QGC | crystal structure of PKM2-K422R mutant | x-ray diffraction | A, B, C, D | — | — |
| 4QGC | Crystal structure of PKM2-K422R mutant | x-ray diffraction | A, B, C, D | — | — |
| 4RPP | crystal structure of PKM2-K422R mutant bound with FBP | x-ray diffraction | A, B, C, D | — | — |
| 4RPP | Crystal structure of PKM2-K422R mutant bound with fbp | x-ray diffraction | A, B, C, D | — | — |
| 4WJ8 | Human Pyruvate Kinase M2 Mutant C424A | x-ray diffraction | A, B, C, D | — | — |
| 4WJ8 | Human pyruvate kinase M2 mutant C424A | x-ray diffraction | A, B, C, D | — | — |
| 4YJ5 | Crystal structure of PKM2 mutant | x-ray diffraction | A, B, C, D | — | — |
| 4YJ5 | Crystal structure of PKM2 mutant | x-ray diffraction | A, B, C, D | — | — |
| 5X0I | Crystal structure of PKM2 R399E mutant complexed with FBP and serine | x-ray diffraction | A, B, C, D | FBP, SER, PYR, MG, K | 20 (best 0.87) |
| 5X0I | Crystal structure of PKM2 R399E mutant complexed with fbp and serine | x-ray diffraction | A, B, C, D | FBP, PYR, MG, K | — |
| 5X1V | PKM2 in complex with compound 2 | x-ray diffraction | A, B, C, D | FBP, 7XX | — |
| 5X1W | PKM2 in complex with compound 5 | x-ray diffraction | A, B, C, D | FBP, 7Y0 | 20 (best 0.88) |
| 5X1W | PKM2 in complex with compound 5 | x-ray diffraction | A, B, C, D | FBP, 7Y0 | — |
| 6B6U | Pyruvate Kinase M2 mutant - S437Y | x-ray diffraction | A, B | MG, OXL, K, CL, SCN | 15 (best 0.87) |
| 6B6U | Pyruvate kinase M2 mutant - S437Y | x-ray diffraction | A, B | MG, OXL, K, CL, SCN | — |
| 6GG3 | Crystal structure of M2 PYK in complex with Alanine. | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | PO4 | — |
| 6GG3 | Crystal structure of M2 pyk in complex with alanine. | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | PO4 | — |
| 6GG4 | Crystal structure of M2 PYK in complex with Phenyalanine. | x-ray diffraction | A, B, C, D | PO4, PHE, K | 20 (best 0.86) |
32 records more on the page itself.
Ligands
- K · Potassium ion · in 24 records
- MG · Magnesium ion · in 24 records
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 22 records
- OXL · Oxalate ion · in 20 records
- CL · Chloride ion · in 12 records
- PO4 · Phosphate ion · in 10 records
- SCN · Thiocyanate ion · in 4 records
- NO3 · Nitrate ion · in 3 records
- 7Y0 · 4-[2,3-bis(chloranyl)phenyl]carbonyl-N-[2-[[4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrol-2-yl]carbonylamino]ethyl]-1-methyl-pyrrole-2-carboxamide · in 2 records
- LZ2 · 5-hydroxynaphthalene-1-sulfonamide · in 2 records
- PHE · Phenylalanine · in 2 records
- PYR · Pyruvic acid · in 2 records
- SER · Serine · in 2 records
- 7XX · 4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrole-2-carboxamide · in 1 record
- ASN · Asparagine · in 1 record
- ASP · Aspartic acid · in 1 record
- NXE · ~{N}-[3-(trifluoromethyl)-1,2-oxazol-5-yl]ethanamide · in 1 record
- NXH · 1-propan-2-yl-3-pyridin-4-yl-urea · in 1 record
- THR · Threonine · in 1 record
- VAL · Valine · in 1 record
Experiment against prediction
- 3G2G chain B against the predicted model P14618: TM-score 1.00, RMSD 0.38 Å
- 3G2G chain B against the predicted model P14618: TM-score 1.00, RMSD 0.38 Å
- 6WP4 chain D against the predicted model P14618: TM-score 1.00, RMSD 0.39 Å
- 6V74 chain D against the predicted model P14618: TM-score 1.00, RMSD 0.37 Å
- 6WP3 chain B against the predicted model P14618: TM-score 1.00, RMSD 0.40 Å
- 6V76 chain D against the predicted model P14618: TM-score 1.00, RMSD 0.40 Å
- 6V74 chain B against the predicted model P14618: TM-score 1.00, RMSD 0.44 Å
- 6V74 chain A against the predicted model P14618: TM-score 1.00, RMSD 0.44 Å
- 8HMR chain A against the predicted model P14618: TM-score 1.00, RMSD 0.45 Å
- 6V76 chain A against the predicted model P14618: TM-score 1.00, RMSD 0.46 Å
Elsewhere
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