UniProt P12689
DNA repair protein REV1 (P12689)
DNA repair protein REV1 (UniProt P12689), EC 2.7.7.-: 43 experimental structures on GenesisL1, 12 ligands bound, 55 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P12689
- Protein
- DNA repair protein REV1
- EC
- 2.7.7.-
- Experimental structures
- 43
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 55 · 10 records with a druggable one
Structures
43 records of P12689 in the MolNFT archive: 43 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AQ4 | Ternary complex of the catalytic core of REV1 with DNA and dCTP. | x-ray diffraction | A | — | — |
| 2AQ4 | Ternary complex of the catalytic core of REV1 with DNA and dctp. | x-ray diffraction | A | — | — |
| 2M2I | NMR solution structure of BRCT domain of yeast REV1 | solution nmr | A | — | — |
| 2M2I | NMR solution structure of brct domain of yeast REV1 | solution nmr | A | — | — |
| 3BJY | Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide | x-ray diffraction | A | — | — |
| 3BJY | Catalytic core of REV1 in complex with DNA (modified template guanine) and incoming nucleotide | x-ray diffraction | A | — | — |
| 3OSP | Structure of rev1 | x-ray diffraction | A | — | — |
| 3OSP | Structure of REV1 | x-ray diffraction | A | — | — |
| 4ID3 | Crystal Structure of the BRCT domain of S. Cerevisiae Rev1 | x-ray diffraction | A, B | — | — |
| 4ID3 | Crystal structure of the brct domain of S. cerevisiae REV1 | x-ray diffraction | A, B | — | — |
| 5UMV | Crystal structure of the BRCT domain of S. cerevisiae Rev1 | x-ray diffraction | A | — | — |
| 5UMV | Crystal structure of the brct domain of S. cerevisiae REV1 | x-ray diffraction | A | — | — |
| 5VX7 | Solution NMR structure of the BRCT domain of S. cerevisiae Rev1 | solution nmr | A | — | — |
| 5VX7 | Solution NMR structure of the brct domain of S. cerevisiae REV1 | solution nmr | A | — | — |
| 5WM1 | Structure of the 10S (+)-trans-BP-dG modified Rev1 ternary complex | x-ray diffraction | A | MG, DCP | — |
| 5WM1 | Structure of the 10S (+)-trans-bp-dg modified REV1 ternary complex | x-ray diffraction | A | MG, DCP | — |
| 5WM8 | Structure of the 10R (+)-cis-bp-dg modified REV1 ternary complex | x-ray diffraction | A | MG, DCP | — |
| 5WMB | Structure of the 10S (-)-cis-bp-dg modified REV1 ternary complex (the bp residue is disordered) | x-ray diffraction | A | MG, DCP | — |
| 5YRQ | Crystal structure of RAD5 and REV1 | x-ray diffraction | A, B, D, E | — | — |
| 6X6Z | Rev1 Ternary Complex with dCTP and Ca2+ | x-ray diffraction | A | CA, DCP | 5 (best 0.84) |
| 6X6Z | REV1 ternary complex with dctp and CA2+ | x-ray diffraction | A | CA, DCP | — |
| 6X70 | Rev1-DNA Binary Complex | x-ray diffraction | A | MG | 6 (best 0.83) |
| 6X70 | REV1-DNA binary complex | x-ray diffraction | A | MG | — |
| 6X71 | Rev1 Mg2+-facilitated Intermediate complex with reactant dCTP and product dCMP | x-ray diffraction | A | MG, DCP, POP | 6 (best 0.82) |
| 6X71 | REV1 MG2+-facilitated intermediate complex with reactant dctp and product dcmp | x-ray diffraction | A | MG, POP | — |
| 6X72 | REV1 MG2+-facilitated product complex with two monophosphates | x-ray diffraction | A | PO4, MG | — |
| 6X73 | Rev1 Mg2+-facilitated Product Complex with one monophosphate | x-ray diffraction | A | MG, PO4, NH4 | 5 (best 0.83) |
| 6X73 | REV1 MG2+-facilitated product complex with one monophosphate | x-ray diffraction | A | MG, PO4, NH4 | — |
| 6X74 | Rev1 Mg2+-facilitated Product Complex with no monophosphates | x-ray diffraction | A | CL, MG | 7 (best 0.85) |
| 6X74 | REV1 MG2+-facilitated product complex with no monophosphates | x-ray diffraction | A | CL, MG | — |
| 6X75 | REV1 MN2+-facilitated product complex with second dctp bound | x-ray diffraction | A | MN, DCP | — |
| 6X76 | REV1 L325G MN2+-facilitated product complex with second dctp bound | x-ray diffraction | A | MN, DCP | — |
| 6X77 | Rev1 R518A Ternary Complex with dCTP and Ca2+ | x-ray diffraction | A | CA, DCP | 4 (best 0.86) |
| 6X77 | REV1 R518A ternary complex with dctp and CA2+ | x-ray diffraction | A | CA, DCP | — |
| 7T18 | Rev1 Ternary Complex with dTTP and Ca2+ | x-ray diffraction | A | CA, TTP | 5 (best 0.85) |
| 7T18 | REV1 ternary complex with dttp and CA2+ | x-ray diffraction | A | CA, TTP | — |
| 7T19 | REV1 ternary complex with dgtp and CA2+ | x-ray diffraction | A | CA, DGT | — |
| 7T1A | Rev1 Ternary Complex with dATP and Ca2+ | x-ray diffraction | A | CA, DTP | 6 (best 0.84) |
| 7T1A | REV1 ternary complex with datp and CA2+ | x-ray diffraction | A | CA, DTP | — |
| 7T1B | Rev1 Ternary Complex with rCTP and Ca2+ | x-ray diffraction | A | CTP, CA | 7 (best 0.82) |
| 7T1B | REV1 ternary complex with rctp and CA2+ | x-ray diffraction | A | CTP, CA | — |
| 8TLT | Cryo-EM structure of Rev1(deltaN)-Polzeta-DNA-dCTP complex | electron microscopy | B | — | 4 (best 0.80) |
| P12689 | AlphaFold monomer V2.0 prediction for DNA repair protein REV1 (P12689) | — | — | — |
Ligands
- MG · Magnesium ion · in 13 records
- CA · Calcium ion · in 11 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 11 records
- PO4 · Phosphate ion · in 3 records
- CL · Chloride ion · in 2 records
- CTP · Cytidine-5'-triphosphate · in 2 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 2 records
- MN · Manganese (II) ion · in 2 records
- NH4 · Ammonium ion · in 2 records
- POP · Pyrophosphate 2- · in 2 records
- TTP · Thymidine-5'-triphosphate · in 2 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 1 record
Elsewhere
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