UniProt P12268
Inosine-5'-monophosphate dehydrogenase 2 (P12268)
Inosine-5'-monophosphate dehydrogenase 2 (UniProt P12268), EC 1.1.1.205: 34 experimental structures on GenesisL1, 9 ligands bound, 200 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P12268
- Protein
- Inosine-5'-monophosphate dehydrogenase 2
- EC
- 1.1.1.205
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 200 · 10 records with a druggable one
Structures
34 records of P12268 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B3O | Ternary complex of human type-II inosine monophosphate dehydrogenase with 6-cl-imp and selenazole… | x-ray diffraction | A, B | — | — |
| 1B3O | Ternary complex of human type-II inosine monophosphate dehydrogenase with 6-cl-imp and selenazole… | x-ray diffraction | A, B | — | — |
| 1NF7 | Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin… | x-ray diffraction | A, B | — | — |
| 1NF7 | Ternary complex of the human type II inosine monophosphate dedhydrogenase with ribavirin… | x-ray diffraction | A, B | — | — |
| 1NFB | Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD | x-ray diffraction | A, B | — | — |
| 1NFB | Ternary complex of the human type II inosine monophosphate dedhydrogenase with 6CL-imp and NAD | x-ray diffraction | A, B | — | — |
| 6I0M | Structure of human imp dehydrogenase, isoform 2, bound to GDP | x-ray diffraction | A, B | 5GP, GDP, SO4 | — |
| 6I0O | Structure of human IMP dehydrogenase, isoform 2, bound to GTP | x-ray diffraction | A, B | GTP, SO4 | — |
| 6I0O | Structure of human imp dehydrogenase, isoform 2, bound to GTP | x-ray diffraction | A, B | GTP, SO4 | — |
| 6U8E | Human IMPDH2 treated with ATP, imp, and NAD+. filament assembly interface reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | — |
| 6U8N | Human IMPDH2 treated with ATP, imp, and NAD+. fully extended filament segment reconstruction. | electron microscopy | I, A, J, B, K, C, L, D, M, E, N, F, O, G, P, H | ATP, IMP, NAD | — |
| 6U8R | Human IMPDH2 treated with ATP, imp, and NAD+. bent (1/4 compressed, 3/4 extended) segment… | electron microscopy | A, B, C, D, E, F, G, H, M, N, O, P, I, J, K, L | IMP, NAD, ATP | — |
| 6U8S | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. filament assembly interface reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | — |
| 6U9O | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. fully compressed filament segment… | electron microscopy | A, I, B, J, C, K, D, L, E, M, F, N, G, O, H, P | GTP, ATP, IMP, NAD | — |
| 6UA2 | Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment… | electron microscopy | A, B, C, D, M, N, O, P, E, F, G, H, I, J, K, L | GTP, ATP, IMP, NAD | — |
| 6UA2 | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. bent (2/4 compressed, 2/4 extended) segment… | electron microscopy | A, B, C, D, M, N, O, P, E, F, G, H, I, J, K, L | GTP, ATP, IMP, NAD | — |
| 6UA4 | Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (3/4 compressed, 1/4 extended) segment… | electron microscopy | A, B, C, D, E, F, G, H, M, N, O, P, I, J, K, L | GTP, ATP, IMP, NAD | 20 (best 0.79) |
| 6UA4 | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. bent (3/4 compressed, 1/4 extended) segment… | electron microscopy | A, B, C, D, E, F, G, H, M, N, O, P, I, J, K, L | GTP, ATP, IMP, NAD | — |
| 6UA5 | Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | 20 (best 0.79) |
| 6UA5 | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. free interfacial octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | — |
| 6UAJ | Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP, NAD | 20 (best 0.79) |
| 6UAJ | Human IMPDH2 treated with ATP, imp, NAD+, and 2 mm GTP. free canonical octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP, IMP, NAD | — |
| 6UC2 | Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP | 20 (best 0.81) |
| 6UC2 | Human IMPDH2 treated with ATP and 2 mm GTP. free canonical octamer reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | GTP, ATP | — |
| 6UDO | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction. | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | IMP, GTP, ATP | 20 (best 0.75) |
| 6UDO | Human IMPDH2 treated with ATP, imp, and 20 mm GTP. fully compressed filament segment reconstruction. | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | IMP, GTP, ATP | — |
| 6UDP | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Filament assembly interface reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP | 20 (best 0.80) |
| 6UDP | Human IMPDH2 treated with ATP, imp, and 20 mm GTP. filament assembly interface reconstruction. | electron microscopy | A, B, C, D, E, F, G, H | IMP | — |
| 6UDQ | Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament end reconstruction. | electron microscopy | I, A, E, J, B, F, K, C, G, L, D, H | IMP, GTP, ATP | 20 (best 0.78) |
| 6UDQ | Human IMPDH2 treated with ATP, imp, and 20 mm GTP. fully compressed filament end reconstruction. | electron microscopy | I, A, E, J, B, F, K, C, G, L, D, H | IMP, GTP, ATP | — |
| 8FOZ | Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; filament assembly interface… | electron microscopy | A, B, C, D, E, F, G, H | IMP, NAD | 20 (best 0.79) |
| 8G8F | Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment… | electron microscopy | A, B, C, D, E, F, G, H | ATP, IMP, NAD | 20 (best 0.78) |
| 9DMU | Cryo-EM structure of IMPDH2 bound to IMP and GAD | electron microscopy | A, B, C, D, E, F, G, H | IMP, A1A7T, K | 20 (best 0.77) |
| P12268 | AlphaFold monomer V2.0 prediction for inosine-5'-monophosphate dehydrogenase 2 (P12268) | — | — | — |
Ligands
- IMP · Inosinic acid · in 22 records
- ATP · Adenosine-5'-triphosphate · in 16 records
- GTP · Guanosine-5'-triphosphate · in 15 records
- NAD · Nicotinamide-adenine-dinucleotide · in 15 records
- SO4 · Sulfate ion · in 3 records
- 5GP · Guanosine-5'-monophosphate · in 1 record
- A1A7T · [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-[3-(thiophen-2-ylcarbonylamino)pyridin-1-yl]oxolan-2-yl]methyl hydrogen phosphate · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- K · Potassium ion · in 1 record
Elsewhere
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