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Ligand · RVP

RVP · Ribavirin monophosphate

RVP, Ribavirin monophosphate (C8 H13 N4 O8 P, 324.2 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
RVP
Formula
C8 H13 N4 O8 P
Class
ligand
Structures
10
PDB entries
5

Binding sites

RVP in 10 structures; the first of them:

  • 1ME7 · Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP and MOA… · RVP A602 · binds ALA57, MET59, ASN291, LYS310, GLY315, GLY316, SER317, ILE318 and 15 more
  • 1ME8 · Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP bound · RVP A602 · binds ALA57, MET59, ASN291, LYS310, GLY315, GLY316, SER317, ILE318 and 15 more
  • 1NF7 · Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin… · RVP A600 · binds SER68, MET70, ASN303, ARG322, SER327, GLY328, SER329, ILE330 and 18 more
  • 1R6A · Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl… · RVP A300 · binds LYS14, LEU17, ASN18, LEU20, GLY21, LYS22, PHE25, LYS29 and 4 more
  • 7DFH · Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin · RVP P1201 · binds LYS545, ARG555, VAL557, CYS622, ASP623, THR680, SER682, THR687 and 5 more
  • 1ME7 · Inosine monophosphate dehydrogenase (impdh) from tritrichomonas foetus with rvp and moa… · RVP A602 · binds ALA57, MET59, ASN291, LYS310, GLY315, GLY316, SER317, ILE318 and 15 more
  • 1ME8 · Inosine monophosphate dehydrogenase (impdh) from tritrichomonas foetus with rvp bound · RVP A602 · binds ALA57, MET59, ASN291, LYS310, GLY315, GLY316, SER317, ILE318 and 15 more
  • 1NF7 · Ternary complex of the human type II inosine monophosphate dedhydrogenase with ribavirin… · RVP A600 · binds SER68, MET70, ASN303, ARG322, SER327, GLY328, SER329, ILE330 and 18 more
  • 1R6A · Structure of the dengue virus 2'O methyltransferase in complex with S-adenosyl… · RVP A300 · binds LYS14, LEU17, ASN18, LEU20, GLY21, LYS22, PHE25, LYS29 and 4 more
  • 7DFH · Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin · RVP P1201 · binds LYS545, ARG555, VAL557, CYS622, ASP623, THR680, SER682, THR687 and 5 more

Residues it binds most

GLY 10, SER 12, MET 8, ILE 8, ASN 12, ASP 10, LYS 8, ARG 10, CYS 8, GLU 4 (residue and the binding sites it lines).

Found with

  • K · Potassium ion
  • NA · Sodium ion
  • MOA · Mycophenolic acid
  • MYD · {[5-(6-amino-purin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphorylmethyl}-phosphonic acid mono-[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-ethyl] ester
  • POP · Pyrophosphate 2-
  • SAH · S-adenosyl-L-homocysteine
  • UNK · Unknown
  • MG · Magnesium ion
  • ZN · Zinc ion
  • SO4 · Sulfate ion

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