UniProt P11716
Ryanodine receptor 1 (P11716)
Ryanodine receptor 1 (UniProt P11716): 91 experimental structures on GenesisL1, 20 ligands bound, 802 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P11716
- Protein
- Ryanodine receptor 1
- Experimental structures
- 91
- Predicted models
- 0
- Ligands
- 20
- Pockets
- 802 · 41 records with a druggable one
Structures
91 records of P11716 in the MolNFT archive: 91 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BCX | Crystal structure of calmodulin in complex with a ryanodine receptor peptide | x-ray diffraction | B | — | — |
| 2BCX | Crystal structure of calmodulin in complex with a ryanodine receptor peptide | x-ray diffraction | B | — | — |
| 2XOA | Crystal Structure of the N-terminal three domains of the skeletal muscle Ryanodine Receptor (RyR1) | x-ray diffraction | A | — | — |
| 2XOA | Crystal structure of the N-terminal three domains of the skeletal muscle ryanodine receptor (RYR1) | x-ray diffraction | A | — | — |
| 3HSM | Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1 | x-ray diffraction | A, B | — | — |
| 3HSM | Crystal structure of distal N-terminal beta-trefoil domain of ryanodine receptor type 1 | x-ray diffraction | A, B | — | — |
| 3ILA | Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9-205) | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3ILA | Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9- 205) | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 3J8H | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | electron microscopy | A, C, E, G | — | — |
| 3RQR | Crystal structure of the RYR domain of the rabbit ryanodine receptor | x-ray diffraction | A | — | — |
| 3RQR | Crystal structure of the ryr domain of the rabbit ryanodine receptor | x-ray diffraction | A | — | — |
| 4ERT | Crystal structure of rabbit ryanodine receptor 1 (2734-2940) | x-ray diffraction | A | — | — |
| 4ERT | Crystal structure of rabbit ryanodine receptor 1 (2734-2940) | x-ray diffraction | A | — | — |
| 4ESU | Crystal structure of rabbit ryanodine receptor 1 mutant S2776M | x-ray diffraction | A | — | — |
| 4ESU | Crystal structure of rabbit ryanodine receptor 1 mutant S2776M | x-ray diffraction | A | — | — |
| 4ETT | Crystal structure of rabbit ryanodine receptor 1 mutant E2764K | x-ray diffraction | A | — | — |
| 4ETT | Crystal structure of rabbit ryanodine receptor 1 mutant E2764K | x-ray diffraction | A | — | — |
| 4ETU | Crystal structure of rabbit ryanodine receptor 1 mutant R2939S | x-ray diffraction | A | — | — |
| 4ETU | Crystal structure of rabbit ryanodine receptor 1 mutant R2939S | x-ray diffraction | A | — | — |
| 4I0Y | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant C36R | x-ray diffraction | A | — | — |
| 4I0Y | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant C36R | x-ray diffraction | A | — | — |
| 4I1E | Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R | x-ray diffraction | A | — | — |
| 4I1E | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant G249R | x-ray diffraction | A | — | — |
| 4I2S | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant I404M | x-ray diffraction | A | — | — |
| 4I2S | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant I404M | x-ray diffraction | A | — | — |
| 4I37 | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant R402G | x-ray diffraction | A | — | — |
| 4I37 | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant R402G | x-ray diffraction | A | — | — |
| 4I3N | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant D61N | x-ray diffraction | A | — | — |
| 4I3N | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant D61N | x-ray diffraction | A | — | — |
| 4I6I | Crystal structure of rabbit ryanodine receptor 1 (residues 1-559) disease mutant R45C | x-ray diffraction | A | — | — |
| 4I6I | Crystal structure of rabbit ryanodine receptor 1 (residues 1-559) disease mutant R45C | x-ray diffraction | A | — | — |
| 4I7I | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant L14R | x-ray diffraction | A | — | — |
| 4I7I | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant L14R | x-ray diffraction | A | — | — |
| 4I8M | Crystal structure of rabbit Ryanodine receptor 1 (residues 1-536) disease mutant V219I | x-ray diffraction | A | — | — |
| 4I8M | Crystal structure of rabbit ryanodine receptor 1 (residues 1-536) disease mutant V219I | x-ray diffraction | A | — | — |
| 4I96 | Crystal structure of the N-terminal two domains of the skeletal muscle ryanodine receptor (rabbit… | x-ray diffraction | A | — | — |
| 4I96 | Crystal structure of the N-terminal two domains of the skeletal muscle ryanodine receptor (rabbit… | x-ray diffraction | A | — | — |
| 4P9J | Crystal Structure of rabbit Ryanodine Receptor 1 SPRY2 Domain (1070-1246) | x-ray diffraction | C, A, B | — | — |
| 4P9J | Crystal structure of rabbit ryanodine receptor 1 SPRY2 domain (1070- 1246) | x-ray diffraction | C, A, B | — | — |
| 4UWA | Structure of the ryanodine receptor at resolution of 6.1 A in closed state | electron microscopy | A, B, C, D | — | — |
| 4UWA | Structure of the ryanodine receptor at resolution of 6.1 a in closed state | electron microscopy | A, B, C, D | — | — |
| 4UWE | Structure of the ryanodine receptor at resolution of 8.5 A in partially open state | electron microscopy | A, B, C, D | — | — |
| 4UWE | Structure of the ryanodine receptor at resolution of 8.5 a in partially open state | electron microscopy | A, B, C, D | — | — |
| 5C30 | Crystal Structure of Rabbit Ryanodine Receptor 1 Repeat12 Domain | x-ray diffraction | A | — | 2 (best 0.69) |
| 5C30 | Crystal structure of rabbit ryanodine receptor 1 REPEAT12 domain | x-ray diffraction | A | — | — |
| 5GKY | Structure of RyR1 in a closed state (C1 conformer) | electron microscopy | A, C, E, G | ZN | 20 (best 0.83) |
| 5GKZ | Structure of RyR1 in a closed state (C3 conformer) | electron microscopy | A, C, E, G | ZN | 20 (best 0.83) |
| 5GL1 | Structure of RyR1 in an open state | electron microscopy | A, C, E, G | ZN | — |
| 5J8V | Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion | electron microscopy | A, B, C, D | — | — |
| 5J8V | Structure of rabbit ryanodine receptor RYR1 open state activated by calcium ion | electron microscopy | A, B, C, D | — | — |
| 5T15 | Structural basis for gating and activation of RyR1 (30 uM Ca2+ dataset, all particles) | electron microscopy | B, E, I, G | ZN, CA | 20 (best 0.85) |
| 5T9M | Structure of rabbit RyR1 (Ca2+-only dataset, class 1) | electron microscopy | B, E, I, G | ZN, CA | 20 (best 0.85) |
| 5T9R | Structure of rabbit RyR1 (Ca2+-only dataset, class 3) | electron microscopy | B, E, I, G | ZN, CA | 20 (best 0.84) |
| 5TAM | Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 4) | electron microscopy | B, E, I, G | ATP, CFF, ZN, CA | 20 (best 0.85) |
| 5TAN | Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 3) | electron microscopy | B, E, I, G | ATP, CFF, ZN, CA | 20 (best 0.86) |
| 5TAT | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 2) | electron microscopy | B, I, E, G | ATP, CFF, ZN | 20 (best 0.85) |
| 5TAV | Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 4) | electron microscopy | B, E, I, G | ATP, CFF, ZN | 20 (best 0.85) |
| 5TAX | Structure of rabbit RyR1 (ryanodine dataset, class 1) | electron microscopy | B, I, G, E | ZN, CA | 20 (best 0.87) |
| 5TAY | Structure of rabbit RyR1 (ryanodine dataset, class 2) | electron microscopy | B, G, I, E | ZN, CA | 20 (best 0.85) |
| 5TB2 | Structure of rabbit RyR1 (EGTA-only dataset, class 2) | electron microscopy | B, I, E, G | ZN | 20 (best 0.86) |
31 records more on the page itself.
Ligands
- ZN · Zinc ion · in 43 records
- CA · Calcium ion · in 23 records
- ATP · Adenosine-5'-triphosphate · in 18 records
- CFF · Caffeine · in 12 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 3 records
- A1BD5 · oxopyricid · in 2 records
- ADE · Adenine · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- CMP · Adenosine-3',5'-cyclic-monophosphate · in 2 records
- A1BD2 · dyphylline · in 1 record
- A1BD4 · allopurinol · in 1 record
- A1LV1 · tetraniliprole · in 1 record
- ADN · Adenosine · in 1 record
- AGS · Phosphothiophosphoric acid-adenylate ester · in 1 record
- AMP · Adenosine monophosphate · in 1 record
- F0U · 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide · in 1 record
- KVR · 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid · in 1 record
- L9R · (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
- U1C · Dantrolene · in 1 record
Elsewhere
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