UniProt P0CE48
Elongation factor Tu 2 (P0CE48)
Elongation factor Tu 2 (UniProt P0CE48), EC 3.6.1.48: 15 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0CE48
- Protein
- Elongation factor Tu 2
- EC
- 3.6.1.48
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 14 · 2 records with a druggable one
Structures
16 records of P0CE48 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OB2 | E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA | x-ray diffraction | A | GLC, FRU, KIR, GNP, MG | 6 (best 0.78) |
| 1OB2 | E. COLI elongation factor ef-tu complexed with the antibiotic kirromycin, a GTP analog, and phe-tRNA | x-ray diffraction | A | — | — |
| 3MMP | Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins | x-ray diffraction | A, C | — | — |
| 3MMP | Structure of the qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins | x-ray diffraction | A, C | — | — |
| 4R71 | Structure of the Qbeta holoenzyme complex in the P1211 crystal form | x-ray diffraction | A, C | — | — |
| 4R71 | Structure of the qbeta holoenzyme complex in the P1211 crystal form | x-ray diffraction | A, C | — | — |
| 4V6K | Structural insights into cognate vs. near-cognate discrimination during decoding. | electron microscopy | BC | — | — |
| 4V6L | Structural insights into cognate vs. near-cognate discrimination during decoding. | electron microscopy | AC | — | — |
| 5WDT | 70S ribosome-EF-Tu H84A complex with GppNHp | electron microscopy | z | MG, PHE, GNP | — |
| 5WE4 | 70S ribosome-EF-Tu wt complex with GppNHp | electron microscopy | z | MG, GNP | — |
| 5WE6 | 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA | electron microscopy | z | PHE, GTP, MG | — |
| 5WFK | 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3) | electron microscopy | z | PHE, GTP | — |
| 6EZE | The open conformation of E.coli Elongation Factor Tu in complex with GDPNP. | x-ray diffraction | A, B | GNP, MG, SO4 | 8 (best 0.58) |
| 6EZE | The open conformation of E.COLI elongation factor tu in complex with gdpnp. | x-ray diffraction | A, B | GNP, MG, SO4 | — |
| 7ABZ | Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome. | electron microscopy | 6 | KIR, GDP | — |
| P0CE48 | AlphaFold monomer V2.0 prediction for elongation factor tu 2 (P0CE48) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 6 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 5 records
- PHE · Phenylalanine · in 3 records
- GTP · Guanosine-5'-triphosphate · in 2 records
- KIR · Kirromycin · in 2 records
- SO4 · Sulfate ion · in 2 records
- FRU · beta-D-fructofuranose · in 1 record
- GDP · Guanosine-5'-diphosphate · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 5WE6 chain z against the predicted model P0CE48: TM-score 0.95, RMSD 1.84 Å
- 5WE4 chain z against the predicted model P0CE48: TM-score 0.94, RMSD 1.80 Å
- 5WDT chain z against the predicted model P0CE48: TM-score 0.94, RMSD 1.92 Å
- 5WFK chain z against the predicted model P0CE48: TM-score 0.94, RMSD 1.97 Å
- 4R71 chain C against the predicted model P0A6P1: TM-score 0.42, RMSD 1.78 Å
- 4R71 chain C against the predicted model P0A6P1: TM-score 0.42, RMSD 1.78 Å
- 1OB2 chain A against the predicted model P0CE48: TM-score 0.93, RMSD 1.94 Å
- 1OB2 chain A against the predicted model P0CE48: TM-score 0.93, RMSD 1.94 Å
- 3MMP chain C against the predicted model P0A6P1: TM-score 0.42, RMSD 1.72 Å
- 3MMP chain C against the predicted model P0A6P1: TM-score 0.42, RMSD 1.72 Å
Elsewhere
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