UniProt P0C6X7
3C-like proteinase (P0C6X7)
3C-like proteinase (UniProt P0C6X7), EC 3.4.22.69: 44 experimental structures on GenesisL1, 11 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P0C6X7
- Protein
- 3C-like proteinase
- EC
- 3.4.22.69
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 8 · 1 record with a druggable one
Structures
44 records of P0C6X7 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UK4 | Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) Complexed With An Inhibitor | x-ray diffraction | A, B | — | — |
| 2XYQ | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 2XYQ | Crystal structure of the NSP16 NSP10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 2XYR | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 2XYR | Crystal structure of the NSP16 NSP10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 2XYV | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 2XYV | Crystal structure of the NSP16 NSP10 SARS coronavirus complex | x-ray diffraction | A, B | — | — |
| 3EBN | A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping | x-ray diffraction | A, B, C, D | — | — |
| 3EBN | A special dimerization of SARS-cov main protease C-terminal domain due to domain-swapping | x-ray diffraction | A, B, C, D | — | — |
| 3R24 | Crystal structure of nsp10/nsp16 complex of SARS coronavirus | x-ray diffraction | A | — | — |
| 3R24 | Crystal structure of NSP10/NSP16 complex of SARS coronavirus | x-ray diffraction | A | — | — |
| 4TWW | Structure of SARS-3CL protease complex with a Bromobenzoyl (S,R)-N-decalin type inhibitor | x-ray diffraction | A, B | — | — |
| 4TWW | Structure of SARS-3CL protease complex with a bromobenzoyl (S,R)-N- decalin type inhibitor | x-ray diffraction | A, B | — | — |
| 4TWY | Structure of SARS-3CL protease complex with a phenylbenzoyl (S,R)-N-decalin type inhibitor | x-ray diffraction | A | — | — |
| 4TWY | Structure of SARS-3CL protease complex with a phenylbenzoyl (S,R)-N- decalin type inhibitor | x-ray diffraction | A | — | — |
| 4WY3 | Structure of SARS-3CL protease complex with a phenylbenzoyl (R,S)-N-decalin type inhibitor | x-ray diffraction | A | — | — |
| 4WY3 | Structure of SARS-3CL protease complex with a phenylbenzoyl (R,S)-N- decalin type inhibitor | x-ray diffraction | A | — | — |
| 5B6O | Crystal structure of MS8104 | x-ray diffraction | A, B | — | — |
| 5B6O | Crystal structure of MS8104 | x-ray diffraction | A, B | — | — |
| 5C5N | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R,S)-N-decalin type inhibitor | x-ray diffraction | A | SLH | 2 (best 0.47) |
| 5C5N | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R, S)-N-decalin type inhibitor | x-ray diffraction | A | — | — |
| 5C5O | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor | x-ray diffraction | A, B | — | — |
| 5C5O | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S, R)-N-decalin type inhibitor | x-ray diffraction | A, B | — | — |
| 5C8S | Crystal structure of the SARS coronavirus NSP14-NSP10 complex with functional ligands sah and gpppa | x-ray diffraction | A, B, C, D | — | — |
| 5C8T | Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM | x-ray diffraction | A, B, C, D | — | — |
| 5C8T | Crystal structure of the SARS coronavirus NSP14-NSP10 complex with functional ligand SAM | x-ray diffraction | A, B, C, D | — | — |
| 5C8U | Crystal structure of the SARS coronavirus NSP14-NSP10 complex | x-ray diffraction | A, B, C, D | — | — |
| 5E6J | Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe | x-ray diffraction | A, D | NI | — |
| 5E6J | Structure of SARS plpro bound to a LYS48-linked di-ubiquitin activity based probe | x-ray diffraction | A, D | — | — |
| 5F22 | C-terminal domain of SARS-CoV nsp8 complex with nsp7 | x-ray diffraction | B | — | — |
| 5F22 | C-terminal domain of SARS-cov NSP8 complex with NSP7 | x-ray diffraction | B | — | — |
| 5N19 | Structure of SARS coronavirus main protease in complex with the alpha- ketoamide… | x-ray diffraction | A | D03 | — |
| 5N5O | Structure of SARS coronavirus main protease in complex with the alpha- ketoamide… | x-ray diffraction | A | 8O5 | — |
| 5TL6 | Crystal structure of SARS-cov papain-like protease in complex with the C-terminal domain of human… | x-ray diffraction | B, D | AYE, ZN, SO4 | — |
| 5TL7 | Crystal structure of SARS-cov papain-like protease in complex with C- terminal domain mouse ISG15 | x-ray diffraction | B, D | AYE, ZN | — |
| 6JYT | Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon… | x-ray diffraction | A, B | ZN | — |
| 6JYT | Delicate structural coordination of the severe acute respiratory syndrome coronavirus NSP13 upon… | x-ray diffraction | A, B | ZN | — |
| 6NUR | SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors | electron microscopy | A, C | ZN | — |
| 6NUR | SARS-coronavirus NSP12 bound to NSP7 and NSP8 co-factors | electron microscopy | A, C | ZN | — |
| 6NUS | SARS-coronavirus NSP12 bound to NSP8 co-factor | electron microscopy | A | ZN | — |
| 7LCP | N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease | x-ray diffraction | A | UED, CA | — |
| 7LCQ | N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease | x-ray diffraction | A | UED | 2 (best 0.52) |
| 7LCQ | N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease | x-ray diffraction | A | UED | — |
| 8C0G | SARS-CoV nsp16-nsp10 complexed with N7-GTP | x-ray diffraction | A, B | SRC, NA, ZN | 4 (best 0.43) |
Ligands
- ZN · Zinc ion · in 8 records
- UED · N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide · in 3 records
- AYE · prop-2-en-1-amine · in 2 records
- 8O5 · (2~{R},3~{S})-3-[[(2~{S})-3-cyclopropyl-2-[[(~{E})-3-phenylprop-2-enoyl]amino]propanoyl]amino]-2-oxidanyl-4-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-~{N}-(phenylmethyl)butanamide · in 1 record
- CA · Calcium ion · in 1 record
- D03 · (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide · in 1 record
- NA · Sodium ion · in 1 record
- NI · Nickel (II) ion · in 1 record
- SLH · (2S)-3-(1H-imidazol-5-yl)-2-({[(3R,4aS,8aR)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal · in 1 record
- SO4 · Sulfate ion · in 1 record
- SRC · [[(2~{R},3~{S},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1,8-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
Elsewhere
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