UniProt P0AEP7
Glyoxylate carboligase (P0AEP7)
Glyoxylate carboligase (UniProt P0AEP7), EC 4.1.1.47: 6 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0AEP7
- Protein
- Glyoxylate carboligase
- EC
- 4.1.1.47
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 80 · 4 records with a druggable one
Structures
7 records of P0AEP7 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2PAN | Crystal structure of E. coli glyoxylate carboligase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2PAN | Crystal structure of E. COLI glyoxylate carboligase | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8BEO | Crystal structure of E. coli glyoxylate carboligase mutant I393A with MAP | x-ray diffraction | A, B, C, D, E, F | MG, FAD, TDK, ALU, UQ0, NA | 20 (best 0.86) |
| 8I01 | Crystal structure of Escherichia coli glyoxylate carboligase | x-ray diffraction | A, B, C, D, E, F | FAD, TPP, MG, UQ0 | 20 (best 0.86) |
| 8I07 | Crystal structure of Escherichia coli glyoxylate carboligase double mutant in complex with… | x-ray diffraction | A, B, C, D, E, F | MG, FAD, TPP, DW3, UQ1 | 20 (best 0.86) |
| 8I08 | Crystal structure of Escherichia coli glyoxylate carboligase quadruple mutant | x-ray diffraction | A, B, C, D, E, F | FAD, TPP, MG, UQ0 | 20 (best 0.85) |
| P0AEP7 | AlphaFold monomer V2.0 prediction for glyoxylate carboligase (P0AEP7) | predicted | A | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 4 records
- MG · Magnesium ion · in 4 records
- TPP · Thiamine diphosphate · in 3 records
- UQ0 · 2,3-dimethoxy-5-methyl-1,4-benzoquinone · in 3 records
- ALU · Methyl hydrogen (S)-acetylphosphonate · in 1 record
- CL · Chloride ion · in 1 record
- DW3 · 2-oxidanylethanal · in 1 record
- NA · Sodium ion · in 1 record
- TDK · 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-hydroxy-1-[(R)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium · in 1 record
- UQ1 · Ubiquinone-1 · in 1 record
Experiment against prediction
- 8BEO chain A against the predicted model P0AEP7: TM-score 1.00, RMSD 0.49 Å
- 8BEO chain E against the predicted model P0AEP7: TM-score 1.00, RMSD 0.49 Å
- 8BEO chain F against the predicted model P0AEP7: TM-score 1.00, RMSD 0.49 Å
- 8BEO chain C against the predicted model P0AEP7: TM-score 1.00, RMSD 0.50 Å
- 8BEO chain B against the predicted model P0AEP7: TM-score 1.00, RMSD 0.51 Å
- 8BEO chain D against the predicted model P0AEP7: TM-score 1.00, RMSD 0.51 Å
- 8I01 chain A against the predicted model P0AEP7: TM-score 0.99, RMSD 0.52 Å
- 8I07 chain E against the predicted model P0AEP7: TM-score 0.99, RMSD 0.52 Å
- 8I07 chain A against the predicted model P0AEP7: TM-score 0.99, RMSD 0.52 Å
- 8I07 chain F against the predicted model P0AEP7: TM-score 0.99, RMSD 0.53 Å
Elsewhere
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