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UniProt P08518

DNA-directed RNA polymerase II subunit RPB2 (P08518)

DNA-directed RNA polymerase II subunit RPB2 (UniProt P08518), EC 2.7.7.6: 278 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction…

UniProt
P08518
Protein
DNA-directed RNA polymerase II subunit RPB2
EC
2.7.7.6
Experimental structures
278
Predicted models
1
Ligands
7
Pockets
80 · 7 records with a druggable one

Structures

279 records of P08518 in the MolNFT archive: 278 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
1I3QRNA polymerase II crystal form I at 3.1 a resolutionx-ray diffractionB——
1I3QRNA polymerase II crystal form I at 3.1 a resolutionx-ray diffractionB——
1I50RNA polymerase II crystal form II at 2.8 a resolutionx-ray diffractionB——
1I50RNA polymerase II crystal form II at 2.8 a resolutionx-ray diffractionB——
1I6HRNA polymerase II elongation complexx-ray diffractionB——
1I6HRNA polymerase II elongation complexx-ray diffractionB——
1K83Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitinx-ray diffractionB——
1K83Crystal structure of yeast RNA polymerase II complexed with the inhibitor alpha amanitinx-ray diffractionB——
1NIKWild Type RNA Polymerase IIx-ray diffractionB——
1NIKWild type RNA polymerase IIx-ray diffractionB——
1NT9Complete 12-subunit RNA polymerase IIx-ray diffractionB——
1NT9Complete 12-subunit RNA polymerase IIx-ray diffractionB——
1PQVRNA polymerase II-TFIIS complexx-ray diffractionB——
1PQVRNA polymerase II-tfiis complexx-ray diffractionB——
1R5URNA polymerase II tfiib complexx-ray diffractionB——
1R5URNA polymerase II tfiib complexx-ray diffractionB——
1R9SRNA polymerase II strand separated elongation complex, matched nucleotidex-ray diffractionB——
1R9SRNA polymerase II strand separated elongation complex, matched nucleotidex-ray diffractionB——
1R9TRNA polymerase II strand separated elongation complex, mismatched nucleotidex-ray diffractionB——
1R9TRNA polymerase II strand separated elongation complex, mismatched nucleotidex-ray diffractionB——
1SFORNA polymerase II strand separated elongation complexx-ray diffractionB——
1SFORNA polymerase II strand separated elongation complexx-ray diffractionB——
1TWARNA polymerase II complexed with ATPx-ray diffractionB——
1TWARNA polymerase II complexed with ATPx-ray diffractionB——
1TWCRNA polymerase II complexed with GTPx-ray diffractionB——
1TWCRNA polymerase II complexed with GTPx-ray diffractionB——
1TWFRNA polymerase II complexed with UTP at 2.3 A resolutionx-ray diffractionB——
1TWFRNA polymerase II complexed with UTP at 2.3 a resolutionx-ray diffractionB——
1TWGRNA polymerase II complexed with CTPx-ray diffractionB——
1TWGRNA polymerase II complexed with CTPx-ray diffractionB——
1TWHRNA polymerase II complexed with 2'dATPx-ray diffractionB——
1TWHRNA polymerase II complexed with 2'DATPx-ray diffractionB——
1WCMComplete 12-Subunit RNA Polymerase II at 3.8 Angstromx-ray diffractionB——
1WCMComplete 12-subunit RNA polymerase II at 3.8 angx-ray diffractionB——
1Y1VRefined RNA Polymerase II-TFIIS complexx-ray diffractionB——
1Y1VRefined RNA polymerase II-tfiis complexx-ray diffractionB——
1Y1WComplete RNA Polymerase II elongation complexx-ray diffractionB——
1Y1WComplete RNA polymerase II elongation complexx-ray diffractionB——
1Y1YRNA Polymerase II-TFIIS-DNA/RNA complexx-ray diffractionB——
1Y1YRNA polymerase II-tfiis-DNA/RNA complexx-ray diffractionB——
1Y77Complete RNA Polymerase II elongation complex with substrate analogue GMPCPPx-ray diffractionB——
1Y77Complete RNA polymerase II elongation complex with substrate analogue gmpcppx-ray diffractionB——
2B63Complete RNA Polymerase II-RNA inhibitor complexx-ray diffractionB——
2B63Complete RNA polymerase II-RNA inhibitor complexx-ray diffractionB——
2B8K12-subunit RNA Polymerase IIx-ray diffractionB——
2B8K12-subunit RNA polymerase IIx-ray diffractionB——
2E2HRNA polymerase II elongation complex at 5 mM Mg2+ with GTPx-ray diffractionB——
2E2HRNA polymerase II elongation complex at 5 mm MG2+ with GTPx-ray diffractionB——
2E2IRNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dGTPx-ray diffractionB——
2E2IRNA polymerase II elongation complex in 5 mm MG+2 with 2'- dgtpx-ray diffractionB——
2E2JRNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPPx-ray diffractionB——
2E2JRNA polymerase II elongation complex in 5 mm MG+2 with gmpcppx-ray diffractionB——
2JA5CPD lesion containing RNA Polymerase II elongation complex Ax-ray diffractionB——
2JA5Cpd lesion containing RNA polymerase II elongation complex ax-ray diffractionB——
2JA6CPD lesion containing RNA Polymerase II elongation complex Bx-ray diffractionB——
2JA6Cpd lesion containing RNA polymerase II elongation complex Bx-ray diffractionB——
2JA7CPD lesion containing RNA Polymerase II elongation complex Cx-ray diffractionB, N——
2JA7Cpd lesion containing RNA polymerase II elongation complex Cx-ray diffractionB, N——
2JA8CPD lesion containing RNA Polymerase II elongation complex Dx-ray diffractionB——
2JA8Cpd lesion containing RNA polymerase II elongation complex Dx-ray diffractionB——

219 records more on the page itself.

Ligands

  • ZN · Zinc ion · in 61 records
  • 2KH · 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine · in 4 records
  • MG · Magnesium ion · in 4 records
  • PPV · Pyrophosphate · in 3 records
  • APC · Diphosphomethylphosphonic acid adenosyl ester · in 2 records
  • WC4 · (1S)-1,4-anhydro-1-(3-methoxynaphthalen-2-yl)-5-O-phosphono-D-ribitol · in 1 record
  • WCG · (1S)-1,4-anhydro-5-O-[(R)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-1-(3-methoxynaphthalen-2-yl)-D-ribitol · in 1 record

Experiment against prediction

Elsewhere

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