UniProt P08514
Integrin alpha-IIb heavy chain (P08514)
Integrin alpha-IIb heavy chain (UniProt P08514): 105 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08514
- Protein
- Integrin alpha-IIb heavy chain
- Experimental structures
- 105
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 48 · 4 records with a druggable one
Structures
106 records of P08514 in the MolNFT archive: 105 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DPK | Solution structure of the cytoplasmic domain of the integrin alpha-iib subunit | solution nmr | A | — | — |
| 1DPK | Solution structure of the cytoplasmic domain of the integrin alpha-iib subunit | solution nmr | A | — | — |
| 1DPQ | Solution structure of the constitutively active mutant of the integrin alpha iib cytoplasmic domain. | solution nmr | A | — | — |
| 1DPQ | Solution structure of the constitutively active mutant of the integrin alpha iib cytoplasmic domain. | solution nmr | A | — | — |
| 1KUP | Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins | solution nmr | A | — | — |
| 1KUP | Solution structure of the membrane proximal regions of alpha-iib and beta-3 integrins | solution nmr | A | — | — |
| 1KUZ | Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins | solution nmr | A | — | — |
| 1KUZ | Solution structure of the membrane proximal regions of alpha-iib and beta-3 integrins | solution nmr | A | — | — |
| 1M8O | Platelet integrin alfaIIb-beta3 cytoplasmic domain | solution nmr | A | — | — |
| 1M8O | Platelet integrin alfaiib-BETA3 cytoplasmic domain | solution nmr | A | — | — |
| 1S4W | NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles | solution nmr | A | — | — |
| 1S4W | NMR structure of the cytoplasmic domain of integrin aiib in dpc micelles | solution nmr | A | — | — |
| 1TYE | Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the… | x-ray diffraction | A, C, E | — | — |
| 1TYE | Structural basis for allostery in integrins and binding of ligand- mimetic therapeutics to the… | x-ray diffraction | A, C, E | — | — |
| 2K1A | Bicelle-embedded integrin alpha(IIB) transmembrane segment | solution nmr | A | — | — |
| 2K1A | Bicelle-embedded integrin ALPHA(IIB) transmembrane segment | solution nmr | A | — | — |
| 2K9J | Integrin alphaIIb-beta3 transmembrane complex | solution nmr | A | — | — |
| 2K9J | Integrin alphaiib-BETA3 transmembrane complex | solution nmr | A | — | — |
| 2KNC | Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | solution nmr | A | — | — |
| 2KNC | Platelet integrin alfaiib-BETA3 transmembrane-cytoplasmic heterocomplex | solution nmr | A | — | — |
| 2MTP | The structure of Filamin repeat 21 bound to integrin | solution nmr | B | — | — |
| 2MTP | The structure of filamin repeat 21 bound to integrin | solution nmr | B | — | — |
| 2N9Y | Structure of the Integrin alphaIIb-beta3(A711P) Transmembrane Complex | solution nmr | A | — | — |
| 2N9Y | Structure of the integrin alphaiib-BETA3(A711P) transmembrane complex | solution nmr | A | — | — |
| 2VC2 | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 | x-ray diffraction | A | — | — |
| 2VC2 | Re-refinement of integrin ALPHAIIBBETA3 headpiece bound to antagonist L-739758 | x-ray diffraction | A | — | — |
| 2VDK | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | x-ray diffraction | A | — | — |
| 2VDK | Re-refinement of integrin ALPHAIIBBETA3 headpiece | x-ray diffraction | A | — | — |
| 2VDL | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | x-ray diffraction | A | — | — |
| 2VDL | Re-refinement of integrin ALPHAIIBBETA3 headpiece | x-ray diffraction | A | — | — |
| 2VDM | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban | x-ray diffraction | A | — | — |
| 2VDM | Re-refinement of integrin ALPHAIIBBETA3 headpiece bound to antagonist tirofiban | x-ray diffraction | A | — | — |
| 2VDN | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide | x-ray diffraction | A | — | — |
| 2VDN | Re-refinement of integrin ALPHAIIBBETA3 headpiece bound to antagonist eptifibatide | x-ray diffraction | A | — | — |
| 2VDO | Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV | x-ray diffraction | A | — | — |
| 2VDO | Integrin ALPHAIIBBETA3 headpiece bound to fibrinogen gamma chain peptide, hhlggakqagdv | x-ray diffraction | A | — | — |
| 2VDP | Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV | x-ray diffraction | A | — | — |
| 2VDP | Integrin ALPHAIIBBETA3 headpiece bound to fibrinogen gamma chain PEPTIDE,LGGAKQAGDV | x-ray diffraction | A | — | — |
| 2VDQ | Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV | x-ray diffraction | A | — | — |
| 2VDQ | Integrin ALPHAIIBBETA3 headpiece bound to a chimeric fibrinogen gamma chain peptide, hhlggakqrgdv | x-ray diffraction | A | — | — |
| 2VDR | Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide, LGGAKQRGDV | x-ray diffraction | A | — | — |
| 2VDR | Integrin ALPHAIIBBETA3 headpiece bound to a chimeric fibrinogen gamma chain peptide, lggakqrgdv | x-ray diffraction | A | — | — |
| 3NID | The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific… | x-ray diffraction | A, C | — | — |
| 3NID | The closed headpiece of integrin alphaiib BETA3 and its complex with an alpahiib BETA3 -specific… | x-ray diffraction | A, C | — | — |
| 3NIF | The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does… | x-ray diffraction | A, C | — | — |
| 3NIF | The closed headpiece of integrin iib 3 and its complex with an iib 3 - specific antagonist that… | x-ray diffraction | A, C | — | — |
| 3NIG | The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does… | x-ray diffraction | A, C | — | — |
| 3NIG | The closed headpiece of integrin iib 3 and its complex with an iib 3 - specific antagonist that… | x-ray diffraction | A, C | — | — |
| 3T3M | A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+… | x-ray diffraction | A, C | — | — |
| 3T3M | A novel high affinity integrin ALPHAIIBBETA3 receptor antagonist that unexpectedly displaces MG2+… | x-ray diffraction | A, C | — | — |
| 3T3P | A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+… | x-ray diffraction | A, C | — | — |
| 3T3P | A novel high affinity integrin ALPHAIIBBETA3 receptor antagonist that unexpectedly displaces MG2+… | x-ray diffraction | A, C | — | — |
| 3ZDX | Integrin alphaIIB beta3 headpiece and RGD peptide complex | x-ray diffraction | A, C | — | — |
| 3ZDX | Integrin alphaiib BETA3 headpiece and rgd peptide complex | x-ray diffraction | A, C | — | — |
| 3ZDY | Integrin alphaIIB beta3 headpiece and RGD peptide complex | x-ray diffraction | A, C | — | — |
| 3ZDY | Integrin alphaiib BETA3 headpiece and rgd peptide complex | x-ray diffraction | A, C | — | — |
| 3ZDZ | Integrin alphaIIB beta3 headpiece and RGD peptide complex | x-ray diffraction | A, C | — | — |
| 3ZDZ | Integrin alphaiib BETA3 headpiece and rgd peptide complex | x-ray diffraction | A, C | — | — |
| 3ZE0 | Integrin alphaIIB beta3 headpiece and RGD peptide complex | x-ray diffraction | A, C | — | — |
| 3ZE0 | Integrin alphaiib BETA3 headpiece and rgd peptide complex | x-ray diffraction | A, C | — | — |
46 records more on the page itself.
Ligands
- CA · Calcium ion · in 30 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 29 records
- SO4 · Sulfate ion · in 29 records
- MAN · alpha-D-mannopyranose · in 25 records
- CL · Chloride ion · in 19 records
- BMA · beta-D-mannopyranose · in 4 records
- MWX · Fradafiban · in 3 records
- I1F · {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid · in 2 records
- I7R · (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl) methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 2 records
- MV8 · (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid · in 2 records
- MWO · (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 2 records
- N9U · Roxifiban · in 2 records
- NB9 · Lamifiban · in 2 records
- XQS · Sibrafiban (active form) · in 2 records
- 5YB · N-(4-carbamimidoylbenzoyl)-beta-alanyl-L-alpha-aspartyl-L-phenylalanine · in 1 record
- IR7 · (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid · in 1 record
- M6K · (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid · in 1 record
- MJX · {4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl}acetic acid · in 1 record
- MWI · Lotrafiban · in 1 record
- NJ9 · 3-(4-{[(5S)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)propanoic acid · in 1 record
- NJF · (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid · in 1 record
Experiment against prediction
- 3ZDX chain C against the predicted model P08514: TM-score 1.00, RMSD 0.54 Å
- 3ZDX chain C against the predicted model P08514: TM-score 1.00, RMSD 0.54 Å
- 3T3P chain C against the predicted model P08514: TM-score 1.00, RMSD 0.55 Å
- 3T3P chain C against the predicted model P08514: TM-score 1.00, RMSD 0.55 Å
- 3NID chain C against the predicted model P08514: TM-score 1.00, RMSD 0.55 Å
- 3NID chain C against the predicted model P08514: TM-score 1.00, RMSD 0.55 Å
- 3NIG chain C against the predicted model P08514: TM-score 1.00, RMSD 0.56 Å
- 3NIG chain C against the predicted model P08514: TM-score 1.00, RMSD 0.56 Å
- 3T3M chain C against the predicted model P08514: TM-score 1.00, RMSD 0.56 Å
- 3T3M chain C against the predicted model P08514: TM-score 1.00, RMSD 0.56 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.