UniProt P08168
S-arrestin (P08168)
S-arrestin (UniProt P08168): 33 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 171 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08168
- Protein
- S-arrestin
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 171 · 11 records with a druggable one
Structures
34 records of P08168 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AYR | Arrestin from bovine rod outer segments | x-ray diffraction | A, B, C, D | — | 18 (best 0.72) |
| 1AYR | Arrestin from bovine rod outer segments | x-ray diffraction | A, B, C, D | — | — |
| 1CF1 | Arrestin from bovine rod outer segments | x-ray diffraction | A, B, C, D | — | 19 (best 0.77) |
| 1CF1 | Arrestin from bovine rod outer segments | x-ray diffraction | A, B, C, D | — | — |
| 3UGU | Crystal Structure of p44 (Splice Variant of Visual Arrestin) | x-ray diffraction | A | — | — |
| 3UGU | Crystal structure of P44 (splice variant of visual arrestin) | x-ray diffraction | A | — | — |
| 3UGX | Crystal Structure of Visual Arrestin | x-ray diffraction | A, B, C, D | — | — |
| 3UGX | Crystal structure of visual arrestin | x-ray diffraction | A, B, C, D | — | — |
| 4J2Q | Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin activation | x-ray diffraction | A, B | — | — |
| 4J2Q | Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin activation | x-ray diffraction | A, B | — | — |
| 4PXF | Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop… | x-ray diffraction | B | — | — |
| 4PXF | Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop… | x-ray diffraction | B | — | — |
| 4ZRG | Visual arrestin mutant - R175E | x-ray diffraction | A | — | — |
| 4ZRG | Visual arrestin mutant - R175E | x-ray diffraction | A | — | — |
| 7F1W | X-ray crystal structure of visual arrestin complexed with inositol hexaphosphate | x-ray diffraction | A, B, D, C | IHP | 13 (best 0.74) |
| 7F1W | X-ray crystal structure of visual arrestin complexed with inositol hexaphosphate | x-ray diffraction | A, B, D, C | IHP | — |
| 7F1X | X-ray crystal structure of visual arrestin complexed with inositol 1,4,5-triphosphate | x-ray diffraction | A, B, C, D | I3P, PTD | 19 (best 0.74) |
| 7F1X | X-ray crystal structure of visual arrestin complexed with inositol 1, 4,5-triphosphate | x-ray diffraction | A, B, C, D | I3P, PTD | — |
| 7JSM | Crystal structure of native bovine arrestin 1 | x-ray diffraction | A, B, C, D | — | 11 (best 0.84) |
| 7JSM | Crystal structure of native bovine arrestin 1 | x-ray diffraction | A, B, C, D | — | — |
| 7JTB | Crystal structure of native bovine arrestin 1 in complex with inositol hexakisphosphate | x-ray diffraction | A, B, C, D | IHP | 11 (best 0.74) |
| 7JTB | Crystal structure of native bovine arrestin 1 in complex with inositol hexakisphosphate | x-ray diffraction | A, B, C, D | IHP | — |
| 7JXA | Crystal structure of native bovine arrestin 1 in complex with inositol 1,4,5-triphosphate | x-ray diffraction | A, B, C, D | I3P, NA, ETX | 12 (best 0.74) |
| 7JXA | Crystal structure of native bovine arrestin 1 in complex with inositol 1,4,5-triphosphate | x-ray diffraction | A, B, C, D | I3P, NA, ETX | — |
| 7MOR | Crystal structure of native bovine arrestin 1 in complex with 5-methylenebiphosphonate inositol… | x-ray diffraction | A, B, C, D | 5A3 | 16 (best 0.73) |
| 7MOR | Crystal structure of native bovine arrestin 1 in complex with 5- methylenebiphosphonate inositol… | x-ray diffraction | A, B, C, D | 5A3 | — |
| 7MP0 | Crystal structure of native bovine arrestin 1 in complex with 1D-myo-inositol 5-diphosphate… | x-ray diffraction | A, B, C, D | ETX, I7P | 15 (best 0.74) |
| 7MP0 | Crystal structure of native bovine arrestin 1 in complex with 1D-myo- inositol 5-diphosphate… | x-ray diffraction | A, B, C, D | ETX, I7P | — |
| 7MP1 | Crystal structure of native bovine arrestin 1 in complex with 1,5-di-methylenebisphosphonate… | x-ray diffraction | A, B, C, D | 4WZ | 16 (best 0.73) |
| 7MP1 | Crystal structure of native bovine arrestin 1 in complex with 1,5-di- methylenebisphosphonate… | x-ray diffraction | A, B, C, D | 4WZ | — |
| 7MP2 | Crystal structure of native bovine arrestin 1 in complex with 1D-myo-inositol 1,5-bisdiphosphate… | x-ray diffraction | A, B, C, D | I8P | 18 (best 0.70) |
| 7MP2 | Crystal structure of native bovine arrestin 1 in complex with 1D-myo- inositol 1,5-bisdiphosphate… | x-ray diffraction | A, B, C, D | I8P | — |
| 9C6E | High-resolution structure of bovine (3-367)Arrestin-1 in a pre-activated conformation | x-ray diffraction | A | GOA, NA | 3 (best 0.40) |
| P08168 | AlphaFold monomer V2.0 prediction for S-arrestin (P08168) | predicted | A | — | — |
Ligands
- ETX · 2-ethoxyethanol · in 4 records
- I3P · D-myo-inositol-1,4,5-triphosphate · in 4 records
- IHP · Inositol hexakisphosphate · in 4 records
- NA · Sodium ion · in 3 records
- 4WZ · {[(1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl]bis[oxy(hydroxyphosphoryl) methanediyl]}bis(phosphonic acid) · in 2 records
- 5A3 · Methylenebisphosphonate inositol pentakisphosphate · in 2 records
- I7P · (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy) cyclohexyl trihydrogen diphosphate · in 2 records
- I8P · (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy) cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] · in 2 records
- PTD · Pentanedial · in 2 records
- GOA · Glycolic acid · in 1 record
Experiment against prediction
- 3UGX chain D against the predicted model P08168: TM-score 0.95, RMSD 1.82 Å
- 3UGX chain D against the predicted model P08168: TM-score 0.95, RMSD 1.82 Å
- 3UGX chain B against the predicted model P08168: TM-score 0.94, RMSD 1.97 Å
- 3UGX chain B against the predicted model P08168: TM-score 0.94, RMSD 1.97 Å
- 3UGX chain C against the predicted model P08168: TM-score 0.94, RMSD 1.91 Å
- 3UGX chain C against the predicted model P08168: TM-score 0.94, RMSD 1.91 Å
- 7F1W chain D against the predicted model P08168: TM-score 0.94, RMSD 1.89 Å
- 7F1W chain D against the predicted model P08168: TM-score 0.94, RMSD 1.89 Å
- 7MP1 chain B against the predicted model P08168: TM-score 0.94, RMSD 2.06 Å
- 7MP1 chain B against the predicted model P08168: TM-score 0.94, RMSD 2.06 Å
Elsewhere
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