MolNFT v1 · #95851 · protein
Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin activation
4J2Q · S-arrestin: “Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin activation”. X-ray diffraction, 9 pockets (best druggability 0.71). MolNFT v1 #95851 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4J2Q
- Type
- protein
- Length
- 686 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-arrestin
- UniProt
- P08168
- Pockets
- 9 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-arrestin | protein | 340 | 4% helix, 52% strand | P08168 |
| B | S-arrestin | protein | 346 | 3% helix, 50% strand | P08168 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.71 | 0.77 | 66 | empty |
| 2 | 447 | 0.60 | 0.75 | 40 | empty |
| 3 | 184 | 0.50 | 0.77 | 25 | empty |
| 4 | 205 | 0.49 | 0.76 | 32 | empty |
| 5 | 63 | 0.40 | 0.81 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1113 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 4J2Q · Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin… · the same entry in another collection · chain A against A, TM-score 1.00
- P08168 · AlphaFold monomer V2.0 prediction for S-arrestin (P08168) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08168
- Elsewhere: RCSB PDB 4J2Q · PDBe 4J2Q · UniProt P08168
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