MolNFT v1 · #3031 · protein

Arrestin from bovine rod outer segments

1CF1 · Protein (arrestin): “Arrestin from bovine rod outer segments”. X-ray diffraction, 19 pockets (best druggability 0.77). MolNFT v1 #3031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1CF1
Type: protein
Length: 1,481 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (arrestin)
UniProt: P08168
Pockets: 19 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 6% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (arrestin)	protein	373	6% helix, 49% strand	P08168
B	Protein (arrestin)	protein	360	7% helix, 52% strand	P08168
C	Protein (arrestin)	protein	380	6% helix, 49% strand	P08168
D	Protein (arrestin)	protein	368	7% helix, 49% strand	P08168

Pockets

19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1092	0.77	0.79	113	empty
2	760	0.74	0.80	82	empty
3	80	0.61	0.89	29	empty
4	79	0.61	0.89	32	empty
5	234	0.60	0.80	36	empty

Interfaces

5 interfaces between chains.

B–C · 1138 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 1117 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 575 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 558 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 20 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1CF1 · Arrestin from bovine rod outer segments · the same entry in another collection · chain D against D, TM-score 1.00
P08168 · AlphaFold monomer V2.0 prediction for S-arrestin (P08168) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08168
Elsewhere: RCSB PDB 1CF1 · PDBe 1CF1 · UniProt P08168

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