UniProt P08004
Chitin synthase 1 (P08004)
Chitin synthase 1 (UniProt P08004), EC 2.4.1.16: 10 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 198 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08004
- Protein
- Chitin synthase 1
- EC
- 2.4.1.16
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 198 · 10 records with a druggable one
Structures
11 records of P08004 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7XS6 | structure of a membrane-integrated glycosyltransferase with inhibitor | electron microscopy | B, A | C14, D12, HP6, BGI, 0V9 | 19 (best 0.87) |
| 7XS7 | structure of a membrane-integrated glycosyltransferase | electron microscopy | B, A | C14, D12, HP6, 0V9 | 20 (best 0.85) |
| 8K3P | S. cerevisiae Chs1 in complex with polyoxin B | electron microscopy | A, B | POV, VDG | 20 (best 0.84) |
| 8K3Q | S. cerevisiae Chs1 in apo state | electron microscopy | A, B | POV | 20 (best 0.85) |
| 8K3R | S. cerevisiae Chs1 in apo state incubated with GlcNAc | electron microscopy | A, B | POV | 20 (best 0.85) |
| 8K3T | S. cerevisiae Chs1 in complex with UDP | electron microscopy | A, B | MG, UDP, POV | 20 (best 0.83) |
| 8K3U | S. cerevisiae Chs1 in complex with UDP and GlcNAc | electron microscopy | A, B | MG, NAG, UDP, POV | 19 (best 0.84) |
| 8K3V | S. cerevisiae Chs1 in complex with UDP-GlcNAc | electron microscopy | A, B | MG, POV, UD1 | 20 (best 0.86) |
| 8K3W | S. cerevisiae Chs1 in complex with UDP-GlcNAc and GlcNAc | electron microscopy | B, A | MG, POV, UD1 | 20 (best 0.86) |
| 8K3X | S. cerevisiae Chs1 in complex with Nikkomycin Z | electron microscopy | A, B | BGI | 20 (best 0.85) |
| P08004 | AlphaFold monomer V2.0 prediction for chitin synthase 1 (P08004) | predicted | A | — | — |
Ligands
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 7 records
- MG · Magnesium ion · in 4 records
- 0V9 · (19R,22S)-25-amino-22-hydroxy-22-oxido-16-oxo-17,21,23-trioxa-22lambda~5~-phosphapentacosan-19-yl (9Z)-hexadec-9-enoate · in 2 records
- BGI · (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2r,3s, 4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3, 4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) · in 2 records
- C14 · Tetradecane · in 2 records
- D12 · Dodecane · in 2 records
- HP6 · Heptane · in 2 records
- UD1 · Uridine-diphosphate-N-acetylglucosamine · in 2 records
- UDP · Uridine-5'-diphosphate · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- VDG · (2S)-2-[[(2S,3S,4S)-5-aminocarbonyloxy-2-azanyl-3,4-bis(oxidanyl)pentanoyl]amino]-2-[(2R,3S,4R,5R)-5-[5-(hydroxymethyl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]ethanoic acid · in 1 record
Experiment against prediction
- 8K3T chain A against the predicted model P08004: TM-score 0.97, RMSD 1.52 Å
- 8K3T chain B against the predicted model P08004: TM-score 0.97, RMSD 1.52 Å
- 8K3P chain A against the predicted model P08004: TM-score 0.97, RMSD 2.03 Å
- 8K3P chain B against the predicted model P08004: TM-score 0.97, RMSD 2.03 Å
- 8K3U chain A against the predicted model P08004: TM-score 0.95, RMSD 2.22 Å
- 8K3U chain B against the predicted model P08004: TM-score 0.95, RMSD 2.22 Å
- 8K3X chain A against the predicted model P08004: TM-score 0.91, RMSD 1.87 Å
- 8K3X chain B against the predicted model P08004: TM-score 0.91, RMSD 1.87 Å
- 8K3W chain B against the predicted model P08004: TM-score 0.91, RMSD 1.94 Å
- 8K3W chain A against the predicted model P08004: TM-score 0.91, RMSD 1.96 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.