UniProt P07333
Macrophage colony-stimulating factor 1 receptor (P07333)
Macrophage colony-stimulating factor 1 receptor (UniProt P07333), EC 2.7.10.1: 42 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 2 pockets. Binding sites, druggability and experiment against…
- UniProt
- P07333
- Protein
- Macrophage colony-stimulating factor 1 receptor
- EC
- 2.7.10.1
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 2 · 1 record with a druggable one
Structures
43 records of P07333 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I0V | c-FMS tyrosine kinase in complex with a quinolone inhibitor | x-ray diffraction | A | — | — |
| 2I0V | C-fms tyrosine kinase in complex with a quinolone inhibitor | x-ray diffraction | A | — | — |
| 2I0Y | cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor | x-ray diffraction | A | — | — |
| 2I0Y | Cfms tyrosine kinase (FGF kid) in complex with an arylamide inhibitor | x-ray diffraction | A | — | — |
| 2I1M | cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor | x-ray diffraction | A | — | — |
| 2I1M | Cfms tyrosine kinase (TIE2 kid) in complex with an arylamide inhibitor | x-ray diffraction | A | — | — |
| 2OGV | Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain | x-ray diffraction | A | — | — |
| 2OGV | Crystal structure of the autoinhibited human C-fms kinase domain | x-ray diffraction | A | — | — |
| 3BEA | cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor | x-ray diffraction | A | — | — |
| 3BEA | Cfms tyrosine kinase (TIE2 kid) in complex with a pyrimidinopyridone inhibitor | x-ray diffraction | A | — | — |
| 3DPK | cFMS tyrosine kinase in complex with a pyridopyrimidi inhibitor | x-ray diffraction | A | — | — |
| 3DPK | Cfms tyrosine kinase in complex with a pyridopyrimidinone inhibitor | x-ray diffraction | A | — | — |
| 3KRJ | cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRJ | Cfms tyrosine kinase in complex with 4-cyano-1H-imidazole-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRL | cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3KRL | Cfms tyrosine kinase in complex with 5-cyano-furan-2-carboxylic acid… | x-ray diffraction | A | — | — |
| 3LCD | Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R | x-ray diffraction | A | — | — |
| 3LCD | Inhibitor bound to a dfg-in structure of the kinase domain of csf-1R | x-ray diffraction | A | — | — |
| 3LCO | Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R | x-ray diffraction | A | — | — |
| 3LCO | Inhibitor bound to a dfg-out structure of the kinase domain of csf-1R | x-ray diffraction | A | — | — |
| 4DKD | Crystal Structure of Human Interleukin-34 Bound to Human CSF-1R | x-ray diffraction | C | — | — |
| 4DKD | Crystal structure of human interleukin-34 bound to human csf-1R | x-ray diffraction | C | — | — |
| 4HW7 | Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME | x-ray diffraction | A | — | — |
| 4HW7 | Crystal structure of fms kinase domain with a small molecular inhibitor, PLX647-ome | x-ray diffraction | A | — | — |
| 4LIQ | Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of… | x-ray diffraction | E | — | — |
| 4LIQ | Structure of the extracellular domain of human csf-1 receptor in complex with the Fab fragment of… | x-ray diffraction | E | — | — |
| 4R7H | Crystal structure of FMS KINASE domain with a small molecular inhibitor, PLX3397 | x-ray diffraction | A | — | — |
| 4R7H | Crystal structure of fms kinase domain with a small molecular inhibitor, PLX3397 | x-ray diffraction | A | — | — |
| 4R7I | Crystal structure of FMS kinase domain with a small molecular inhibitor, GLEEVEC | x-ray diffraction | A | — | — |
| 4R7I | Crystal structure of fms kinase domain with a small molecular inhibitor, gleevec | x-ray diffraction | A | — | — |
| 4WRL | Structure of the human CSF-1:CSF-1R complex | x-ray diffraction | A, C | — | — |
| 4WRL | Structure of the human csf-1:CSF-1R complex | x-ray diffraction | A, C | — | — |
| 4WRM | Structure of the human CSF-1:CSF-1R complex | x-ray diffraction | A | — | — |
| 4WRM | Structure of the human csf-1:CSF-1R complex | x-ray diffraction | A | — | — |
| 6IG8 | Crystal structure of csf-1R kinase domain with a small molecular inhibitor, jte-952 | x-ray diffraction | A | MG, A7O | — |
| 6N33 | Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622 | x-ray diffraction | A | 622 | — |
| 6N33 | Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622 | x-ray diffraction | A | 622 | — |
| 6T2W | Crystal structure of the CSF1R kinase domain with a dihydropurinone inhibitor (compound 4) | x-ray diffraction | A | M9T, SO4 | — |
| 6WXJ | CSF1R signaling is a regulator of pathogenesis in progressive ms | x-ray diffraction | A | UF4 | — |
| 7MFC | Crystal structure of CSF1R in complex with vimseltinib | x-ray diffraction | A | Z6V | — |
| 7TNH | Crystal structure of CSF1R kinase domain in complex with dp-6233 | x-ray diffraction | A | NA, CL, I9W | — |
| 8JOT | Crystal structure of CSF-1R kinase domain with sulfatinib | x-ray diffraction | A | UKI | 2 (best 0.66) |
| P07333 | AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor (P07333) | predicted | A | — | — |
Ligands
- 622 · 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl) methyl]pyridin-2-amine · in 2 records
- A7O · (3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2S)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone · in 1 record
- CL · Chloride ion · in 1 record
- I9W · 2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide · in 1 record
- M9T · 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- UF4 · 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine · in 1 record
- UKI · Sulfatinib · in 1 record
- Z6V · Vimseltinib · in 1 record
Experiment against prediction
- 4LIQ chain E against the predicted model P07333: TM-score 0.98, RMSD 1.25 Å
- 4LIQ chain E against the predicted model P07333: TM-score 0.98, RMSD 1.25 Å
- 4HW7 chain A against the predicted model P07333: TM-score 0.97, RMSD 1.20 Å
- 4HW7 chain A against the predicted model P07333: TM-score 0.97, RMSD 1.20 Å
- 7MFC chain A against the predicted model P07333: TM-score 0.97, RMSD 1.26 Å
- 6N33 chain A against the predicted model P07333: TM-score 0.96, RMSD 1.36 Å
- 6N33 chain A against the predicted model P07333: TM-score 0.96, RMSD 1.36 Å
- 4R7I chain A against the predicted model P07333: TM-score 0.96, RMSD 1.40 Å
- 4R7I chain A against the predicted model P07333: TM-score 0.96, RMSD 1.40 Å
- 3LCO chain A against the predicted model P07333: TM-score 0.96, RMSD 1.57 Å
Elsewhere
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