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Ligand · 8C5

8C5 · 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

8C5, 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide (C27 H34 N6 O3, 490.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
8C5
Formula
C27 H34 N6 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

8C5 in 2 structures; the first of them:

  • 3DPK · cFMS tyrosine kinase in complex with a pyridopyrimidi inhibitor · 8C5 A923 · binds THR587, LEU588, GLY589, VAL596, ALA614, LYS616, GLU633, MET637 and 11 more
  • 3DPK · Cfms tyrosine kinase in complex with a pyridopyrimidinone inhibitor · 8C5 A923 · binds THR587, LEU588, GLY589, VAL596, ALA614, LYS616, GLU633, MET637 and 11 more

Residues it binds most

ALA 2, GLU 2, GLY 2, LEU 2, THR 2, VAL 2, ARG 2, ASP 2, CYS 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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