Cfms tyrosine kinase in complex with a pyridopyrimidinone inhibitor

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).

Ligands and binding sites

• 8C5 · 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide · ligand · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3DPK · cFMS tyrosine kinase in complex with a pyridopyrimidi inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
• P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.93
• P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07333
• Every structure of UniProt P11362
• Elsewhere: RCSB PDB 3DPK · PDBe 3DPK · UniProt P07333 · UniProt P11362