UniProt P07260
Eukaryotic translation initiation factor 4E (P07260)
Eukaryotic translation initiation factor 4E (UniProt P07260): 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P07260
- Protein
- Eukaryotic translation initiation factor 4E
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 15 · 2 records with a druggable one
Structures
11 records of P07260 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AP8 | Translation initiation factor EIF4E in complex with M7GDP, NMR, 20 structures | solution nmr | A | — | — |
| 1AP8 | Translation initiation factor EIF4E in complex with M7GDP, NMR, 20 structures | solution nmr | A | — | — |
| 1RF8 | Solution structure of the yeast translation initiation factor eIF4E in complex with m7GDP and… | solution nmr | A | — | — |
| 1RF8 | Solution structure of the yeast translation initiation factor EIF4E in complex with M7GDP and… | solution nmr | A | — | — |
| 6FC1 | Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state | x-ray diffraction | A, C | MGP | 6 (best 0.53) |
| 6FC1 | Crystal structure of the EIF4E-EAP1P complex from saccharomyces cerevisiae in the cap-bound state | x-ray diffraction | A, C | MGP | — |
| 6FC2 | Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae | x-ray diffraction | A, C | CA | 6 (best 0.80) |
| 6FC2 | Crystal structure of the EIF4E-EAP1P complex from saccharomyces cerevisiae | x-ray diffraction | A, C | CA | — |
| 6FC3 | Crystal structure of the eIF4E-p20 complex from Saccharomyces cerevisiae | x-ray diffraction | A | ZN | 2 (best 0.45) |
| 6FC3 | Crystal structure of the EIF4E-P20 complex from saccharomyces cerevisiae | x-ray diffraction | A | ZN | — |
| P07260 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P07260) | predicted | A | — | 1 (best 0.49) |
Ligands
Experiment against prediction
- 6FC2 chain C against the predicted model P07260: TM-score 0.97, RMSD 0.87 Å
- 6FC2 chain C against the predicted model P07260: TM-score 0.97, RMSD 0.87 Å
- 6FC2 chain A against the predicted model P07260: TM-score 0.97, RMSD 1.12 Å
- 6FC2 chain A against the predicted model P07260: TM-score 0.97, RMSD 1.12 Å
- 6FC1 chain C against the predicted model P07260: TM-score 0.94, RMSD 0.83 Å
- 6FC1 chain C against the predicted model P07260: TM-score 0.94, RMSD 0.83 Å
- 6FC1 chain A against the predicted model P07260: TM-score 0.93, RMSD 0.78 Å
- 6FC1 chain A against the predicted model P07260: TM-score 0.93, RMSD 0.78 Å
- 6FC3 chain A against the predicted model P07260: TM-score 0.93, RMSD 1.75 Å
- 6FC3 chain A against the predicted model P07260: TM-score 0.93, RMSD 1.75 Å
Elsewhere
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