MolNFT v1 · #148625 · protein
Crystal structure of the EIF4E-P20 complex from saccharomyces cerevisiae
6FC3 · Eukaryotic translation initiation factor 4E: “Crystal structure of the EIF4E-P20 complex from saccharomyces cerevisiae”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.45). MolNFT v1 #148625 on GenesisL1: 3D…
- PDB
- 6FC3
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Cap-associated protein CAF20
- UniProt
- P07260, P12962
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 173 | 32% helix, 30% strand | P07260 |
| B | Cap-associated protein CAF20 | protein | 46 | 52% helix, 0% strand | P12962 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.45 | 0.76 | 21 | empty |
| 2 | 52 | 0.34 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1508 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6FC3 · Crystal structure of the eIF4E-p20 complex from Saccharomyces cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- P07260 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P07260) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P12962 · AlphaFold monomer V2.0 prediction for cap-associated protein CAF20 (P12962) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07260
- Every structure of UniProt P12962
- Elsewhere: RCSB PDB 6FC3 · PDBe 6FC3 · UniProt P07260 · UniProt P12962
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