UniProt P07143
Cytochrome c1, heme protein, mitochondrial (P07143)
Cytochrome c1, heme protein, mitochondrial (UniProt P07143), EC 1.10.2.2, 7.1.1.8: 26 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 68 pockets. Binding sites, druggability and experiment against…
- UniProt
- P07143
- Protein
- Cytochrome c1, heme protein, mitochondrial
- EC
- 1.10.2.2, 7.1.1.8
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 68 · 9 records with a druggable one
Structures
27 records of P07143 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KB9 | Yeast cytochrome BC1 complex | x-ray diffraction | D | PCF, PIE, CDL, HEM | 11 (best 0.84) |
| 1KB9 | Yeast cytochrome BC1 complex | x-ray diffraction | D | — | — |
| 1KYO | Yeast cytochrome BC1 complex with bound substrate cytochrome C | x-ray diffraction | D, O | HEC | 10 (best 0.85) |
| 1KYO | Yeast cytochrome BC1 complex with bound substrate cytochrome C | x-ray diffraction | D, O | — | — |
| 1P84 | HDBT inhibited Yeast Cytochrome bc1 Complex | x-ray diffraction | D | HEC, 3PH, PC1, CDL | 10 (best 0.83) |
| 1P84 | Hdbt inhibited yeast cytochrome BC1 complex | x-ray diffraction | D | — | — |
| 2IBZ | Yeast Cytochrome BC1 Complex with Stigmatellin | x-ray diffraction | D | — | — |
| 2IBZ | Yeast cytochrome BC1 complex with stigmatellin | x-ray diffraction | D | — | — |
| 3CX5 | Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core… | x-ray diffraction | D, O | — | — |
| 3CX5 | Structure of complex III with bound cytochrome C in reduced state and definition of a minimal core… | x-ray diffraction | D, O | — | — |
| 3CXH | Structure of yeast complex III with isoform-2 cytochrome c bound and definition of a minimal core… | x-ray diffraction | D, O | — | — |
| 3CXH | Structure of yeast complex III with isoform-2 cytochrome C bound and definition of a minimal core… | x-ray diffraction | D, O | — | — |
| 4PD4 | Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of… | x-ray diffraction | D | — | — |
| 4PD4 | Structural analysis of atovaquone-inhibited cytochrome BC1 complex reveals the molecular basis of… | x-ray diffraction | D | — | — |
| 6GIQ | Saccharomyces cerevisiae respiratory supercomplex III2IV | electron microscopy | D, O | 6PH, HEM, 7PH, CN3 | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | — |
| 6HU9 | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | — |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | 7 (best 0.83) |
| 6T0B | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | — |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | 7 (best 0.83) |
| 6T15 | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | — |
| 6YMX | CIII2/CIV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | D, O | 6PH, HEM, PTY, 7PH, CN3 | 9 (best 0.82) |
| 6YMX | CIII2/CIV respiratory supercomplex from saccharomyces cerevisiae | electron microscopy | D, O | 6PH, HEM, PTY, 7PH, CN3 | — |
| 8E7S | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | electron microscopy | L, l | CDL, PEF, HEM | 3 (best 0.81) |
| 8EC0 | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | electron microscopy | L, l | PEF, HEM, PGT, PCF | 6 (best 0.87) |
| 9ETZ | III2IV respiratory supercomplex from Saccharomyces cerevisiae | electron microscopy | D, O | PEF, HEC, CDL | 5 (best 0.84) |
| P07143 | AlphaFold monomer V2.0 prediction for cytochrome C1, heme protein, mitochondrial (P07143) | predicted | A | — | — |
Ligands
- CDL · Cardiolipin · in 10 records
- HEC · Heme C · in 9 records
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 9 records
- HEM · Protoporphyrin IX containing Fe · in 6 records
- 6PH · (1R)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate · in 3 records
- 7PH · (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate · in 3 records
- CN3 · (2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate · in 3 records
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 2 records
- PTY · Phosphatidylethanolamine · in 2 records
- 3PH · 1,2-diacyl-glycerol-3-sn-phosphate · in 1 record
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 1 record
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
- PIE · 1,2-diacyl-sn-glycero-3-phosphoinositol · in 1 record
Experiment against prediction
- 2IBZ chain D against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 2IBZ chain D against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 1KYO chain O against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 1KYO chain O against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 1KYO chain D against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 1KYO chain D against the predicted model P07143: TM-score 0.99, RMSD 0.60 Å
- 3CXH chain O against the predicted model P07143: TM-score 0.99, RMSD 0.63 Å
- 3CXH chain O against the predicted model P07143: TM-score 0.99, RMSD 0.63 Å
- 1KB9 chain D against the predicted model P07143: TM-score 0.99, RMSD 0.63 Å
- 1KB9 chain D against the predicted model P07143: TM-score 0.99, RMSD 0.63 Å
Elsewhere
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