UniProt P06756
Integrin alpha-V (P06756)
Integrin alpha-V (UniProt P06756): 74 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 357 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P06756
- Protein
- Integrin alpha-V
- Experimental structures
- 74
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 357 · 34 records with a druggable one
Structures
75 records of P06756 in the MolNFT archive: 74 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U8C | A novel adaptation of the integrin PSI domain revealed from its crystal structure | x-ray diffraction | A | — | — |
| 1U8C | A novel adaptation of the integrin psi domain revealed from its crystal structure | x-ray diffraction | A | — | — |
| 3IJE | Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane… | x-ray diffraction | A | — | — |
| 3IJE | Crystal structure of the complete integrin ALHAVBETA3 ectodomain plus an ALPHA/BETA transmembrane… | x-ray diffraction | A | — | — |
| 4G1E | Crystal structure of integrin alpha V beta 3 with coil-coiled tag. | x-ray diffraction | A | — | — |
| 4G1E | Crystal structure of integrin alpha V beta 3 with coil-coiled tag. | x-ray diffraction | A | — | — |
| 4G1M | Re-refinement of alpha V beta 3 structure | x-ray diffraction | A | — | — |
| 4G1M | Re-refinement of alpha V beta 3 structure | x-ray diffraction | A | — | — |
| 4MMX | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | x-ray diffraction | A | — | — |
| 4MMX | Integrin ALPHAVBETA3 ectodomain bound to the tenth domain of fibronectin | x-ray diffraction | A | — | — |
| 4MMY | Integrin ALPHAVBETA3 ectodomain bound to the tenth domain of fibronectin with the iakgdwnd motif | x-ray diffraction | A | — | — |
| 4MMZ | Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin | x-ray diffraction | A | — | — |
| 4MMZ | Integrin ALPHAVBETA3 ectodomain bound to an antagonistic tenth domain of fibronectin | x-ray diffraction | A | — | — |
| 4O02 | AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. | x-ray diffraction | A | — | — |
| 4O02 | ALPHAVBETA3 integrin in complex with monoclonal antibody Fab fragment. | x-ray diffraction | A | — | — |
| 4UM8 | Crystal structure of alpha V beta 6 | x-ray diffraction | A, C | — | — |
| 4UM8 | Crystal structure of alpha V beta 6 | x-ray diffraction | A, C | — | — |
| 4UM9 | Crystal structure of alpha V beta 6 with peptide | x-ray diffraction | A, C | — | — |
| 5FFG | Crystal structure of integrin alpha V beta 6 head | x-ray diffraction | A | NAG, BMA, MAN, CA, SO4 | 7 (best 0.82) |
| 5FFG | Crystal structure of integrin alpha V beta 6 head | x-ray diffraction | A | — | — |
| 5FFO | Integrin alpha V beta 6 in complex with pro-TGF-beta | x-ray diffraction | A, E | NAG, MAN, BMA, CA | — |
| 5FFO | Integrin alpha V beta 6 in complex with pro-TGF-beta | x-ray diffraction | A, E | — | — |
| 5NEM | Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A. | electron microscopy | A | NAG, MAN, CA | 7 (best 0.81) |
| 5NEM | Localised reconstruction of alpha V beta 6 bound to foot and mouth disease virus O panasia - pose a. | electron microscopy | A | NAG, MAN, CA | — |
| 5NER | Localised reconstruction of alpha v beta 6 bound to Foot and Mouth Disease Virus O PanAsia - Pose A… | electron microscopy | A | NAG, MAN, CA | 6 (best 0.81) |
| 5NER | Localised reconstruction of alpha V beta 6 bound to foot and mouth disease virus O panasia - pose a… | electron microscopy | A | NAG, MAN, CA | — |
| 5NET | Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa… | electron microscopy | A | NAG, MAN, CA | 7 (best 0.80) |
| 5NET | Localised reconstruction of integrin alpha V beta 6 bound to foot and mouth disease virus O1 manisa… | electron microscopy | A | NAG, MAN, CA | — |
| 5NEU | Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa… | electron microscopy | A | — | 4 (best 0.83) |
| 5NEU | Localised reconstruction of integrin alpha V beta 6 bound to foot and mouth disease virus O1 manisa… | electron microscopy | A | — | — |
| 6AVQ | The therapeutic antibody LM609 selectively inhibits ligand binding to human alpha-V beta-3 integrin… | electron microscopy | A | — | — |
| 6AVR | Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody… | electron microscopy | A | — | 12 (best 0.84) |
| 6AVR | Human alpha-V beta-3 integrin (intermediate conformation) in complex with the therapeutic antibody… | electron microscopy | A | — | — |
| 6AVU | Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 | electron microscopy | A | — | 14 (best 0.84) |
| 6AVU | Human alpha-V beta-3 integrin (open conformation) in complex with the therapeutic antibody LM609 | electron microscopy | A | — | — |
| 6DJP | Integrin alpha-V beta-8 in complex with the fabs 8B8 and 68 | electron microscopy | A | NAG | — |
| 6MK0 | Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161 | x-ray diffraction | A | NAG, BMA, MAN, MN, JUY | 12 (best 0.80) |
| 6MK0 | Integrin ALPHAVBETA3 ectodomain bound to antagonist tdi-4161 | x-ray diffraction | A | NAG, BMA, MAN, MN, JUY | — |
| 6MSL | Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D | x-ray diffraction | A | NAG, BMA, MAN, MN | 11 (best 0.80) |
| 6MSL | Integrin ALPHAVBETA3 ectodomain bound to eeti-II 2.5D | x-ray diffraction | A | NAG, BMA, MAN, MN | — |
| 6MSU | Integrin alphaVBeta3 in complex with EETI-II 2.5F | x-ray diffraction | A | NAG, BMA, MAN, MN | 15 (best 0.79) |
| 6MSU | Integrin ALPHAVBETA3 in complex with eeti-II 2.5F | x-ray diffraction | A | NAG, BMA, MAN, MN | — |
| 6NAJ | Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin. | x-ray diffraction | A | NAG, BMA, MN | — |
| 6NAJ | Integrin ALPHAVBETA3 ectodomain bound to HR10 variant of the 10TH domain of fibronectin. | x-ray diffraction | A | NAG, BMA, MN | — |
| 6OM1 | Crystal structure of an atypical integrin | x-ray diffraction | A, C, E, G | NAG, BMA, MAN, CA | 19 (best 0.85) |
| 6OM1 | Crystal structure of an atypical integrin | x-ray diffraction | A, C, E, G | NAG, BMA, MAN, CA | — |
| 6OM2 | Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide | x-ray diffraction | A, C | NAG, BMA, MAN, CA, GLY | 16 (best 0.80) |
| 6OM2 | Crystal structure of atypical integrin alphav BETA8 with protgf-BETA1 ligand peptide | x-ray diffraction | A, C | NAG, BMA, MAN, CA | — |
| 6UJA | Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | electron microscopy | A | NAG, BMA, MAN, CA | 10 (best 0.79) |
| 6UJA | Integrin alpha-V beta-8 in complex with pro-TGF-BETA1 | electron microscopy | A | NAG, BMA, MAN, CA | — |
| 6UJB | Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2 | electron microscopy | A | NAG, BMA, MAN, CA | 10 (best 0.79) |
| 6UJB | Integrin alpha-V beta-8 in complex with the fabs C6D4 and 11D12V2 | electron microscopy | A | NAG, BMA, MAN, CA | — |
| 6UJC | Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2 | electron microscopy | A | NAG, BMA, MAN, CA | 11 (best 0.77) |
| 6UJC | Integrin alpha-V beta-8 in complex with the fabs C6-RGD3 and 11D12V2 | electron microscopy | A | NAG, BMA, MAN, CA | — |
| 7Y1T | Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2 | electron microscopy | A | NAG, BMA, CA | 11 (best 0.81) |
| 7Y1T | Complex of integrin ALPHAV/BETA8 and L-TGF-BETA1 at a ratio of 1:2 | electron microscopy | A | NAG, BMA, CA | — |
| 8IJ5 | Cryo-EM structure of Integrin AVB3 | electron microscopy | E | — | 12 (best 0.81) |
| 8TCF | Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf | electron microscopy | A | NAG, BMA, MAN, CA | 12 (best 0.81) |
| 8TCG | Integrin alpha-v beta-6 in complex with minibinder B6_BP_dslf | electron microscopy | A | NAG, MAN, CA | 9 (best 0.82) |
| 8VS6 | L-TGF-b3/avb8 | electron microscopy | A | NAG, BMA, MAN, CA | 8 (best 0.79) |
15 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 38 records
- MAN · alpha-D-mannopyranose · in 33 records
- BMA · beta-D-mannopyranose · in 30 records
- CA · Calcium ion · in 29 records
- MN · Manganese (II) ion · in 8 records
- A1LU4 · 2-[(2~{R},5~{R},8~{S},11~{S})-11-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid · in 2 records
- JUY · (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1, 8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid · in 2 records
- A1A6A · (2S)-phenyl{(3S)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid · in 1 record
- A1A6B · (2S)-(2-cyclopropylphenyl){(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid · in 1 record
- A1A6H · (2S)-{5-fluoro-2-[(2S)-oxan-2-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid · in 1 record
- A1A6I · (2S)-{5-fluoro-2-[(6S)-5-oxaspiro[2.5]octan-6-yl]phenyl}{(3R)-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]pyrrolidin-1-yl}acetic acid · in 1 record
- A1AFA · N-(2,4-dichlorobenzoyl)-L-phenylalanine · in 1 record
- A1LU7 · 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid · in 1 record
- GLY · Glycine · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 8VS6 chain A against the predicted model P06756: TM-score 1.00, RMSD 0.49 Å
- 6DJP chain A against the predicted model P06756: TM-score 0.99, RMSD 0.66 Å
- 8XEK chain A against the predicted model P06756: TM-score 0.99, RMSD 0.69 Å
- 8IJ5 chain E against the predicted model P06756: TM-score 0.99, RMSD 0.69 Å
- 8XEL chain A against the predicted model P06756: TM-score 0.99, RMSD 0.82 Å
- 8TCG chain A against the predicted model P06756: TM-score 0.99, RMSD 0.70 Å
- 4UM9 chain C against the predicted model P06756: TM-score 0.99, RMSD 0.90 Å
- 6UJA chain A against the predicted model P06756: TM-score 0.99, RMSD 0.93 Å
- 6UJA chain A against the predicted model P06756: TM-score 0.99, RMSD 0.93 Å
- 5NER chain A against the predicted model P06756: TM-score 0.99, RMSD 0.92 Å
Elsewhere
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