UniProt P05107
Integrin beta-2 (P05107)
Integrin beta-2 (UniProt P05107): 38 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 152 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05107
- Protein
- Integrin beta-2
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 152 · 10 records with a druggable one
Structures
39 records of P05107 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1L3Y | Integrin EGF-like module 3 from the beta-2 subunit | solution nmr | A | — | — |
| 1L3Y | Integrin EGF-like module 3 from the beta-2 subunit | solution nmr | A | — | — |
| 1YUK | The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8… | x-ray diffraction | A, B | NDG | 1 (best 0.39) |
| 1YUK | The crystal structure of the PSI/HYBRID domain/ I-EGF1 segment from the human integrin BETA2 at 1.8… | x-ray diffraction | A, B | NDG | 1 (best 0.39) |
| 2JF1 | Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail… | x-ray diffraction | T | — | — |
| 2JF1 | Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail… | x-ray diffraction | T | — | — |
| 2P26 | Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | x-ray diffraction | A | NAG | 1 (best 0.50) |
| 2P26 | Structure of the PHE2 and PHE3 fragments of the integrin BETA2 subunit | x-ray diffraction | A | NAG | 1 (best 0.50) |
| 2P28 | Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | x-ray diffraction | A, B | NAG | 1 (best 0.33) |
| 2P28 | Structure of the PHE2 and PHE3 fragments of the integrin BETA2 subunit | x-ray diffraction | A, B | NAG | 1 (best 0.33) |
| 3K6S | Structure of integrin alphaXbeta2 ectodomain | x-ray diffraction | B, D, F, H | NAG, CA | 18 (best 0.87) |
| 3K6S | Structure of integrin ALPHAXBETA2 ectodomain | x-ray diffraction | B, D, F, H | — | — |
| 3K71 | Structure of integrin alphaX beta2 ectodomain | x-ray diffraction | B, D, F, H | NAG, CA | 18 (best 0.85) |
| 3K71 | Structure of integrin alphax BETA2 ectodomain | x-ray diffraction | B, D, F, H | — | — |
| 3K72 | Structure of integrin alphaX beta2 | x-ray diffraction | B, D | NAG, CA | 16 (best 0.83) |
| 3K72 | Structure of integrin alphax BETA2 | x-ray diffraction | B, D | NAG, CA | 16 (best 0.83) |
| 4NEH | An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 | x-ray diffraction | B | NAG, CA, MG | 11 (best 0.82) |
| 4NEH | An internal ligand-bound, metastable state of a leukocyte integrin, AXB2 | x-ray diffraction | B | — | — |
| 4NEN | An internal ligand-bound, metastable state of a leukocyte integrin, aXb2 | x-ray diffraction | B | NAG, CA, MG | 14 (best 0.82) |
| 4NEN | An internal ligand-bound, metastable state of a leukocyte integrin, AXB2 | x-ray diffraction | B | — | — |
| 5E6R | Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the… | x-ray diffraction | B | CA, NAG | 8 (best 0.83) |
| 5E6R | Structures of leukocyte integrin ALB2: the ai domain, the headpiece, and the pocket for the… | x-ray diffraction | B | — | — |
| 5E6S | Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the… | x-ray diffraction | B, D, F | CA, NAG | 17 (best 0.85) |
| 5E6S | Structures of leukocyte integrin ALB2: the ai domain, the headpiece, and the pocket for the… | x-ray diffraction | B, D, F | — | — |
| 5E6U | Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the… | x-ray diffraction | B | MG, CA, NAG | 7 (best 0.83) |
| 5E6U | Structures of leukocyte integrin ALB2: the ai domain, the headpiece, and the pocket for the… | x-ray diffraction | B | — | — |
| 5E6V | Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid… | x-ray diffraction | A | NAG | — |
| 5E6V | Re-refinement of the crystal structure of the plexin-semaphorin- integrin DOMAIN/HYBRID… | x-ray diffraction | A | — | — |
| 5E6W | Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid… | x-ray diffraction | A | NAG | 1 (best 0.34) |
| 5E6W | Re-refinement of the crystal structure of the plexin-semaphorin- integrin DOMAIN/HYBRID… | x-ray diffraction | A | — | — |
| 5E6X | Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid… | x-ray diffraction | A | NAG | 1 (best 0.50) |
| 5E6X | Re-refinement of the crystal structure of the plexin-semaphorin- integrin DOMAIN/HYBRID… | x-ray diffraction | A | — | — |
| 5ES4 | Re-refinement of integrin ALPHAXBETA2 ectodomain in the CLOSED/BENT conformation | x-ray diffraction | B, D, F, H | NAG, MAN, CA | 19 (best 0.84) |
| 5ES4 | Re-refinement of integrin ALPHAXBETA2 ectodomain in the CLOSED/BENT conformation | x-ray diffraction | B, D, F, H | — | — |
| 5XR1 | Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2 | solution nmr | A | — | — |
| 5XR1 | Structure of fln IG21 domain in complex with C-terminal peptide of beta-2 | solution nmr | A | — | — |
| 5ZAZ | Solution structure of integrin b2 monomer tranmembrane domain in bicelle | solution nmr | A | — | — |
| 5ZAZ | Solution structure of integrin B2 monomer tranmembrane domain in bicelle | solution nmr | A | — | — |
| P05107 | AlphaFold monomer V2.0 prediction for integrin beta-2 (P05107) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4NEH chain B against the predicted model P05107: TM-score 0.96, RMSD 2.03 Å
- 4NEH chain B against the predicted model P05107: TM-score 0.96, RMSD 2.03 Å
- 3K72 chain B against the predicted model P05107: TM-score 0.95, RMSD 2.08 Å
- 3K72 chain B against the predicted model P05107: TM-score 0.95, RMSD 2.08 Å
- 1YUK chain A against the predicted model P05107: TM-score 0.95, RMSD 1.07 Å
- 1YUK chain A against the predicted model P05107: TM-score 0.95, RMSD 1.07 Å
- 3K71 chain B against the predicted model P05107: TM-score 0.95, RMSD 2.09 Å
- 3K71 chain B against the predicted model P05107: TM-score 0.95, RMSD 2.09 Å
- 5ES4 chain B against the predicted model P05107: TM-score 0.94, RMSD 2.37 Å
- 5ES4 chain B against the predicted model P05107: TM-score 0.94, RMSD 2.37 Å
Elsewhere
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