MolNFT v1 · #47560 · protein
Structure of the PHE2 and PHE3 fragments of the integrin BETA2 subunit
2P28 · Integrin beta-2: “Structure of the PHE2 and PHE3 fragments of the integrin BETA2 subunit”. X-ray diffraction, 1 ligand (NAG), 1 pocket (best druggability 0.33). MolNFT v1 #47560 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2P28
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin beta-2
- UniProt
- P05107
- Ligands
- NAG
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin beta-2 | protein | 96 | 23% helix, 29% strand | P05107 |
| B | Integrin beta-2 | protein | 214 | 5% helix, 42% strand | P05107 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.33 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2209 Ų buried · 37 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05107
- Elsewhere: RCSB PDB 2P28 · PDBe 2P28 · UniProt P05107
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