MolNFT v1 · #41156 · protein

Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail peptide

2JF1 · Filamin-a: “Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail peptide”. X-ray diffraction. MolNFT v1 #41156 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2JF1
Type: protein
Length: 98 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Filamin-a; Integrin beta-2 subunit
UniProt: P21333, P05107

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 60% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Filamin-a	protein	87	7% helix, 57% strand	P21333
T	Integrin beta-2 subunit	protein	11	0% helix, 82% strand	P05107

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–T · 654 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2JF1 · Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2… · the same entry in another collection · chain A against A, TM-score 1.00
P21333 · AlphaFold monomer V2.0 prediction for filamin-a (P21333) · a predicted model of the same protein · chain A against A, TM-score 0.97
P05107 · AlphaFold monomer V2.0 prediction for integrin beta-2 (P05107) · a predicted model of the same protein · chain T against A, TM-score 0.46

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21333
Every structure of UniProt P05107
Elsewhere: RCSB PDB 2JF1 · PDBe 2JF1 · UniProt P21333 · UniProt P05107

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