UniProt P21333
Filamin-A (P21333)
Filamin-A (UniProt P21333): 46 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21333
- Protein
- Filamin-A
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 14 · 3 records with a druggable one
Structures
47 records of P21333 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AAV | Solution NMR structure of Filamin A domain 17 | solution nmr | A | — | — |
| 2AAV | Solution NMR structure of filamin a domain 17 | solution nmr | A | — | — |
| 2BP3 | Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex | x-ray diffraction | A, B | — | — |
| 2BP3 | Crystal structure of filamin a domain 17 and gpib alpha cytoplasmic domain complex | x-ray diffraction | A, B | — | — |
| 2BRQ | Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail… | x-ray diffraction | A, B | — | — |
| 2BRQ | Crystal structure of the filamin a repeat 21 complexed with the integrin BETA7 cytoplasmic tail… | x-ray diffraction | A, B | — | — |
| 2J3S | Crystal structure of the human filamin A Ig domains 19 to 21 | x-ray diffraction | A, B | — | — |
| 2J3S | Crystal structure of the human filamin a ig domains 19 to 21 | x-ray diffraction | A, B | — | — |
| 2JF1 | Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail… | x-ray diffraction | A | — | — |
| 2JF1 | Crystal structure of the filamin a repeat 21 complexed with the integrin BETA2 cytoplasmic tail… | x-ray diffraction | A | — | — |
| 2K3T | Solution Structure of IG-Like Domain 23 from Human Filamin A | solution nmr | A | — | — |
| 2K3T | Solution structure of ig-like domain 23 from human filamin a | solution nmr | A | — | — |
| 2K7P | Filamin A Ig-like domains 16-17 | solution nmr | A | — | — |
| 2K7P | Filamin a ig-like domains 16-17 | solution nmr | A | — | — |
| 2K7Q | Filamin A Ig-like domains 18-19 | solution nmr | A | — | — |
| 2K7Q | Filamin a ig-like domains 18-19 | solution nmr | A | — | — |
| 2MTP | The structure of Filamin repeat 21 bound to integrin | solution nmr | A | — | — |
| 2MTP | The structure of filamin repeat 21 bound to integrin | solution nmr | A | — | — |
| 2W0P | Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide | x-ray diffraction | A, B | — | — |
| 2W0P | Crystal structure of the filamin a repeat 21 complexed with the migfilin peptide | x-ray diffraction | A, B | — | — |
| 2WFN | Filamin A actin binding domain | x-ray diffraction | A, B | — | — |
| 2WFN | Filamin a actin binding domain | x-ray diffraction | A, B | — | — |
| 3CNK | Crystal Structure of the dimerization domain of human filamin A | x-ray diffraction | A, B | — | — |
| 3CNK | Crystal structure of the dimerization domain of human filamin a | x-ray diffraction | A, B | — | — |
| 3HOC | Structure of the actin-binding domain of human filamin A mutant E254K | x-ray diffraction | A, B | — | — |
| 3HOC | Structure of the actin-binding domain of human filamin a mutant E254K | x-ray diffraction | A, B | — | — |
| 3HOP | Structure of the actin-binding domain of human filamin A | x-ray diffraction | A, B | — | — |
| 3HOP | Structure of the actin-binding domain of human filamin a | x-ray diffraction | A, B | — | — |
| 3HOR | Structure of the actin-binding domain of human filamin A (reduced) | x-ray diffraction | A, B | — | — |
| 3HOR | Structure of the actin-binding domain of human filamin a (reduced) | x-ray diffraction | A, B | — | — |
| 3ISW | Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR | x-ray diffraction | A, B | — | — |
| 3ISW | Crystal structure of filamin-a immunoglobulin-like repeat 21 bound to an N-terminal peptide of cftr | x-ray diffraction | A, B | — | — |
| 3RGH | Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens | x-ray diffraction | A, B | — | — |
| 3RGH | Structure of filamin a immunoglobulin-like repeat 10 from homo sapiens | x-ray diffraction | A, B | — | — |
| 4M9P | Crystal structure of the human filamin A Ig-like domains 3-5 | x-ray diffraction | A | — | — |
| 4M9P | Crystal structure of the human filamin a ig-like domains 3-5 | x-ray diffraction | A | — | — |
| 4P3W | Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide | x-ray diffraction | A, B, E, F, D, C | — | — |
| 4P3W | Crystal structure of the human filamin a ig-like domains 20-21 in complex with migfilin peptide | x-ray diffraction | A, B, E, F, D, C | — | — |
| 5XR1 | Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2 | solution nmr | A | — | — |
| 5XR1 | Structure of fln IG21 domain in complex with C-terminal peptide of beta-2 | solution nmr | A | — | — |
| 6D8C | Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin | electron microscopy | D, A, B, C, E | — | 10 (best 0.71) |
| 6D8C | Cryo-EM structure of flnaabd E254K bound to phalloidin-stabilized F- actin | electron microscopy | D, A, B, C, E | — | — |
| 6EW1 | Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q | x-ray diffraction | A | — | — |
| 6EW1 | Crystal structure of the filamin a ig-like domains 3-5 mutant P637Q | x-ray diffraction | A | — | — |
| 7SC4 | filamin complex-1 | x-ray diffraction | A, B | SO4 | 3 (best 0.55) |
| 7SFT | Filamin complex-2 | solution nmr | A | — | 1 (best 0.60) |
| P21333 | AlphaFold monomer V2.0 prediction for filamin-a (P21333) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 3HOR chain A against the predicted model P21333: TM-score 0.99, RMSD 0.47 Å
- 3HOR chain A against the predicted model P21333: TM-score 0.99, RMSD 0.47 Å
- 3HOC chain A against the predicted model P21333: TM-score 0.98, RMSD 0.80 Å
- 3HOC chain A against the predicted model P21333: TM-score 0.98, RMSD 0.80 Å
- 2WFN chain A against the predicted model P21333: TM-score 0.98, RMSD 0.86 Å
- 2WFN chain A against the predicted model P21333: TM-score 0.98, RMSD 0.86 Å
- 2WFN chain B against the predicted model P21333: TM-score 0.98, RMSD 0.86 Å
- 2WFN chain B against the predicted model P21333: TM-score 0.98, RMSD 0.86 Å
- 4M9P chain A against the predicted model P21333: TM-score 0.98, RMSD 0.94 Å
- 4M9P chain A against the predicted model P21333: TM-score 0.98, RMSD 0.94 Å
Elsewhere
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