UniProt P04439
HLA class I histocompatibility antigen, A alpha chain (P04439)
HLA class I histocompatibility antigen, A alpha chain (UniProt P04439): 55 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 207 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P04439
- Protein
- HLA class I histocompatibility antigen, A alpha chain
- Experimental structures
- 55
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 207 · 42 records with a druggable one
Structures
56 records of P04439 in the MolNFT archive: 55 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XPG | Crystal structure of a MHC class I-peptide complex | x-ray diffraction | A | — | 4 (best 0.67) |
| 2XPG | Crystal structure of a MHC class I-peptide complex | x-ray diffraction | A | — | 4 (best 0.67) |
| 3RL1 | HIV RT derived peptide complexed to HLA-A*0301 | x-ray diffraction | A | — | 4 (best 0.68) |
| 3RL1 | HIV rt derived peptide complexed to HLA-A*0301 | x-ray diffraction | A | — | — |
| 3RL2 | HIV Nef derived peptide Nef73 complexed to HLA-A*0301 | x-ray diffraction | A | — | 4 (best 0.66) |
| 3RL2 | HIV nef derived peptide NEF73 complexed to HLA-A*0301 | x-ray diffraction | A | — | — |
| 6ENY | Structure of the human PLC editing module | electron microscopy | F | NAG | 6 (best 0.84) |
| 6ENY | Structure of the human plc editing module | electron microscopy | F | NAG | — |
| 6O9B | Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide | x-ray diffraction | A | — | 4 (best 0.72) |
| 6O9B | Crystal structure of HLA-A3*01 in complex with a wild-type beta- catenin peptide | x-ray diffraction | A | — | — |
| 6O9C | Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide | x-ray diffraction | A | SO4 | 4 (best 0.71) |
| 6O9C | Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide | x-ray diffraction | A | SO4 | — |
| 7L1B | Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide | x-ray diffraction | A | — | 4 (best 0.68) |
| 7L1B | Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide | x-ray diffraction | A | — | — |
| 7L1C | Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | 4 (best 0.69) |
| 7L1C | Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | — |
| 7L1D | Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | 5 (best 0.71) |
| 7L1D | Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | — |
| 7MLE | Crystal Structure of HLA-A*03:01 in complex with VVRPSVASK, an 9-mer epitope from Influenza B virus | x-ray diffraction | A | SO4 | 4 (best 0.70) |
| 7MLE | Crystal structure of HLA-A*03:01 in complex with vvrpsvask, an 9-mer epitope from influenza B virus | x-ray diffraction | A | SO4 | — |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor-associated peptide-MHC I | electron microscopy | H | — | 5 (best 0.70) |
| 7PHR | Structure of a fully assembled T-cell receptor engaging a tumor- associated peptide-MHC I | electron microscopy | H | — | — |
| 7QPD | Structure of the human MHC I peptide-loading complex editing module | electron microscopy | M | NAG | 9 (best 0.76) |
| 7QPD | Structure of the human MHC I peptide-loading complex editing module | electron microscopy | M | NAG | — |
| 7RK7 | The complex between TIL 1383i TCR and human Class I MHC HLA-A2 with the bound… | x-ray diffraction | A | — | 7 (best 0.68) |
| 7RM4 | Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2 | x-ray diffraction | A, F, K, P | — | 16 (best 0.69) |
| 7RM4 | Neoantigen P53R175H-specific TCR 6-11 binds to P53R175H-HLA-A2 | x-ray diffraction | A, F, K, P | — | — |
| 7RRG | Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | 6 (best 0.69) |
| 7RRG | Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | — |
| 7STF | Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2 | electron microscopy | A | — | 6 (best 0.72) |
| 7UC5 | Crystal Structure of HLA A*0301 in complex with ILRGSVAHK, a 9-mer epitope from Influenza A | x-ray diffraction | A, D | SO4 | 8 (best 0.74) |
| 7UX3 | Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes | electron microscopy | Y | — | 2 (best 0.52) |
| 8D4C | beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | Y, P | — | 4 (best 0.75) |
| 8D4D | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | Y, P | — | 2 (best 0.70) |
| 8D4E | Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes | electron microscopy | Y | — | 3 (best 0.62) |
| 8D4F | beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | Y, P | — | 1 (best 0.62) |
| 8D4G | gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide… | electron microscopy | Y, P | — | 2 (best 0.76) |
| 8D9R | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on… | electron microscopy | Y, y, z, 0, 1, 2 | — | 1 (best 0.68) |
| 8D9S | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated wide membrane tubes, centered on beta-Arf1 | electron microscopy | Y, y, z, 0, 1, 2 | — | 2 (best 0.76) |
| 8D9T | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on… | electron microscopy | Y, x, y, z, 0, 1 | — | — |
| 8D9U | AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes, centered on… | electron microscopy | Y, x, y, z, 0, 1 | — | 3 (best 0.76) |
| 8D9V | gamma-Arf1 homodimeric interface within AP-1, Arf1, Nef lattice on narrow membrane tubes | electron microscopy | Y, P | — | 2 (best 0.75) |
| 8D9W | beta-Arf1 homodimeric interface within AP-1, Arf1, Nef, MHC-I lattice on narrow tubes | electron microscopy | Y, j | — | 4 (best 0.71) |
| 8DVG | Structure of KRAS WT(7-16)-HLA-A*03:01 | x-ray diffraction | A | SO4 | 5 (best 0.70) |
| 8RRO | G12V-TCR complex with HLA-A3 | x-ray diffraction | C, H, M, R, W, b, g, l | — | 14 (best 0.73) |
| 8RYM | Structure of S2 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide | x-ray diffraction | A | — | 7 (best 0.69) |
| 8RYO | Structure of S2-198 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide | x-ray diffraction | A | TOE | 8 (best 0.67) |
| 8RYP | Structure of S8 TCR in complex with HLA-A*03:01 bound to ELFSYLIEK peptide | x-ray diffraction | A | — | 7 (best 0.68) |
| 8UDR | Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide presented by the… | electron microscopy | A | MOV | 5 (best 0.78) |
| 8VCL | Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide | x-ray diffraction | A | — | 4 (best 0.68) |
| 8VJZ | HLA-A*03:01 with WT KRAS-10mer | x-ray diffraction | A | — | 4 (best 0.69) |
| 8VR9 | Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide… | electron microscopy | A | MOV | 7 (best 0.80) |
| 8VRA | Structure of a synthetic antibody in complex with a class I MHC presenting a hapten-peptide… | electron microscopy | A | MOV | 6 (best 0.83) |
| 9ASF | Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide analogue (Trp-6 Bta) | x-ray diffraction | A | — | 4 (best 0.70) |
| 9ASG | Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide analogue (Trp-6 Bta) | x-ray diffraction | A | — | 4 (best 0.69) |
| P04439 | AlphaFold monomer V2.0 prediction for HLA class I histocompatibility antigen, a alpha chain (P04439) | predicted | A | — | 2 (best 0.57) |
Ligands
Experiment against prediction
- 8VRA chain A against the predicted model P04439: TM-score 0.99, RMSD 0.55 Å
- 8VR9 chain A against the predicted model P04439: TM-score 0.99, RMSD 0.57 Å
- 8RYP chain A against the predicted model P04439: TM-score 0.99, RMSD 0.58 Å
- 7RRG chain A against the predicted model P04439: TM-score 0.99, RMSD 0.62 Å
- 7RRG chain A against the predicted model P04439: TM-score 0.99, RMSD 0.62 Å
- 8RRO chain H against the predicted model P04439: TM-score 0.99, RMSD 0.61 Å
- 7PHR chain H against the predicted model P04439: TM-score 0.99, RMSD 0.62 Å
- 7PHR chain H against the predicted model P04439: TM-score 0.99, RMSD 0.62 Å
- 8RRO chain C against the predicted model P04439: TM-score 0.99, RMSD 0.61 Å
- 8RRO chain l against the predicted model P04439: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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