MolNFT v1 · #186683 · protein
Neoantigen P53R175H-specific TCR 6-11 binds to P53R175H-HLA-A2
7RM4 · HLA class I histocompatibility antigen, a alpha chain: “Neoantigen P53R175H-specific TCR 6-11 binds to P53R175H-HLA-A2”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #186683 on GenesisL1: 3D structure, binding…
- PDB
- 7RM4
- Type
- protein
- Length
- 3,308 residues
- Chains
- 20
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, a alpha chain; Beta-2-microglobulin; Cellular…
- UniProt
- P04439, P61769, P04637
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 5 distinct chains · 11% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F, K, P | HLA class I histocompatibility antigen, a alpha chain | protein | 275 | 25% helix, 39% strand | P04439 |
| B, G, L, Q | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C, H, M, R | Cellular tumor antigen P53 peptide | protein | 9 | 0% helix, 0% strand | P04637 |
| D, I, N, S | 6-11 T cell receptor beta chain | protein | 243 | 4% helix, 49% strand | — |
| E, J, O, T | 6-11 T cell receptor alpha chain | protein | 200 | 5% helix, 48% strand | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 797 | 0.73 | 0.78 | 65 | empty |
| 2 | 1002 | 0.73 | 0.76 | 79 | empty |
| 3 | 1157 | 0.72 | 0.76 | 92 | empty |
| 4 | 1052 | 0.72 | 0.76 | 86 | empty |
| 5 | 613 | 0.69 | 0.78 | 57 | empty |
Interfaces
36 interfaces between chains.
- N–O · 2353 Ų buried · 28 hydrogen bonds · protein-protein
- I–J · 2314 Ų buried · 25 hydrogen bonds · protein-protein
- D–E · 2284 Ų buried · 24 hydrogen bonds · protein-protein
- S–T · 2283 Ų buried · 30 hydrogen bonds · protein-protein
- P–Q · 1451 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide (disulfide).
Compared structures
- 7RM4 · Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2 · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04439
- Every structure of UniProt P61769
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 7RM4 · PDBe 7RM4 · UniProt P04439 · UniProt P61769 · UniProt P04637
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.