UniProt P04637
Cellular tumor antigen p53 (P04637)
Cellular tumor antigen p53 (UniProt P04637): 432 experimental structures on GenesisL1, 45 ligands bound, 263 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P04637
- Protein
- Cellular tumor antigen p53
- Experimental structures
- 432
- Predicted models
- 0
- Ligands
- 45
- Pockets
- 263 · 38 records with a druggable one
Structures
432 records of P04637 in the MolNFT archive: 432 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A1U | Solution structure determination of a P53 mutant dimerization domain, NMR, minimized average… | solution nmr | A, C | — | — |
| 1A1U | Solution structure determination of a P53 mutant dimerization domain, NMR, minimized average… | solution nmr | A, C | — | — |
| 1AIE | P53 tetramerization domain crystal structure | x-ray diffraction | A | — | — |
| 1AIE | P53 tetramerization domain crystal structure | x-ray diffraction | A | — | — |
| 1C26 | Crystal structure of P53 tetramerization domain | x-ray diffraction | A | — | — |
| 1C26 | Crystal structure of P53 tetramerization domain | x-ray diffraction | A | — | — |
| 1DT7 | Solution structure of the C-terminal negative regulatory domain of P53 in a complex with CA2+-bound… | solution nmr | X, Y | — | — |
| 1DT7 | Solution structure of the C-terminal negative regulatory domain of P53 in a complex with CA2+-bound… | solution nmr | X, Y | — | — |
| 1GZH | Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor | x-ray diffraction | A, C | — | — |
| 1GZH | Crystal structure of the brct domains of human 53BP1 bound to the P53 tumor supressor | x-ray diffraction | A, C | — | — |
| 1H26 | CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53 | x-ray diffraction | E | — | — |
| 1H26 | CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P53 | x-ray diffraction | E | — | — |
| 1HS5 | NMR solution structure of designed P53 dimer | solution nmr | A, B | — | — |
| 1HS5 | NMR solution structure of designed P53 dimer | solution nmr | A, B | — | — |
| 1JSP | NMR Structure of CBP Bromodomain in complex with p53 peptide | solution nmr | A | — | — |
| 1JSP | NMR structure of cbp bromodomain in complex with P53 peptide | solution nmr | A | — | — |
| 1KZY | Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 | x-ray diffraction | A, B | — | — |
| 1KZY | Crystal structure of the 53BP1 brct region complexed to tumor suppressor P53 | x-ray diffraction | A, B | — | — |
| 1MA3 | Structure of a Sir2 enzyme bound to an acetylated p53 peptide | x-ray diffraction | B | — | — |
| 1MA3 | Structure of a SIR2 enzyme bound to an acetylated P53 peptide | x-ray diffraction | B | — | — |
| 1OLG | High-resolution solution structure of the oligomerization domain of P53 by multi-dimensional NMR | solution nmr | A, B, C, D | — | — |
| 1OLG | High-resolution solution structure of the oligomerization domain of P53 by multi-dimensional NMR | solution nmr | A, B, C, D | — | — |
| 1OLH | High-resolution solution structure of the oligomerization domain of P53 by multi-dimensional NMR | solution nmr | A, B, C, D | — | — |
| 1OLH | High-resolution solution structure of the oligomerization domain of P53 by multi-dimensional NMR | solution nmr | A, B, C, D | — | — |
| 1PES | NMR solution structure of the tetrameric minimum transforming domain of P53 | solution nmr | A, B, C, D | — | — |
| 1PES | NMR solution structure of the tetrameric minimum transforming domain of P53 | solution nmr | A, B, C, D | — | — |
| 1PET | NMR solution structure of the tetrameric minimum transforming domain of P53 | solution nmr | A, B, C, D | — | — |
| 1PET | NMR solution structure of the tetrameric minimum transforming domain of P53 | solution nmr | A, B, C, D | — | — |
| 1SAE | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAE | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAF | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAF | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAK | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAK | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAL | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1SAL | High resolution solution NMR structure of the oligomerization domain of P53 by multi-dimensional… | solution nmr | A, B, C, D | — | — |
| 1TSR | P53 core domain in complex with DNA | x-ray diffraction | A, B, C | — | — |
| 1TSR | P53 core domain in complex with DNA | x-ray diffraction | A, B, C | — | — |
| 1TUP | Tumor suppressor P53 complexed with DNA | x-ray diffraction | A, B, C | — | — |
| 1TUP | Tumor suppressor P53 complexed with DNA | x-ray diffraction | A, B, C | — | — |
| 1UOL | Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution. | x-ray diffraction | A, B | — | — |
| 1UOL | Crystal structure of the human P53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 a resolution. | x-ray diffraction | A, B | — | — |
| 1XQH | Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a… | x-ray diffraction | B, F | — | — |
| 1XQH | Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a… | x-ray diffraction | B, F | — | — |
| 1YCQ | Xenopus laevis MDM2 bound to the transactivation domain of human P53 | x-ray diffraction | B | — | — |
| 1YCQ | Xenopus laevis MDM2 bound to the transactivation domain of human P53 | x-ray diffraction | B | — | — |
| 1YCR | MDM2 bound to the transactivation domain of P53 | x-ray diffraction | B | — | — |
| 1YCR | MDM2 bound to the transactivation domain of P53 | x-ray diffraction | B | — | — |
| 1YCS | P53-53BP2 complex | x-ray diffraction | A | — | — |
| 1YCS | P53-53BP2 complex | x-ray diffraction | A | — | — |
| 2AC0 | Structural Basis of DNA Recognition by p53 Tetramers (complex I) | x-ray diffraction | A, B, C, D | — | — |
| 2AC0 | Structural basis of DNA recognition by P53 tetramers (complex I) | x-ray diffraction | A, B, C, D | — | — |
| 2ADY | Structural Basis of DNA Recognition by p53 Tetramers (complex IV) | x-ray diffraction | A, B | — | — |
| 2ADY | Structural basis of DNA recognition by P53 tetramers (complex IV) | x-ray diffraction | A, B | — | — |
| 2AHI | Structural Basis of DNA Recognition by p53 Tetramers (complex III) | x-ray diffraction | A, B, C, D | — | — |
| 2AHI | Structural basis of DNA recognition by P53 tetramers (complex III) | x-ray diffraction | A, B, C, D | — | — |
| 2ATA | Structural Basis of DNA Recognition by p53 Tetramers (complex II) | x-ray diffraction | A, B, C, D | — | — |
| 2ATA | Structural basis of DNA recognition by P53 tetramers (complex II) | x-ray diffraction | A, B, C, D | — | — |
| 2B3G | p53N (fragment 33-60) bound to RPA70N | x-ray diffraction | B | — | — |
| 2B3G | P53N (fragment 33-60) bound to RPA70N | x-ray diffraction | B | — | — |
372 records more on the page itself.
Ligands
- ZN · Zinc ion · in 109 records
- QNN · (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · in 15 records
- QN8 · (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · in 13 records
- ARS · Arsenic · in 7 records
- MG · Magnesium ion · in 7 records
- SO4 · Sulfate ion · in 5 records
- FOR · Formyl group · in 4 records
- LEK · 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine · in 4 records
- EXQ · [9-ethyl-7-(4-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium · in 3 records
- 6SM · 5-chloranylpyrimidine-4-carboxylic acid · in 2 records
- 9GH · 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1, 3-benzothiazole-4-carboxylic acid · in 2 records
- 9GN · 3-iodanyl-2-oxidanyl-5-propylsulfanyl-4-pyrrol-1-yl-benzoic acid · in 2 records
- 9GQ · 5-butoxy-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid · in 2 records
- 9GW · 3-iodanyl-2-oxidanyl-5-propoxy-4-pyrrol-1-yl-benzoic acid · in 2 records
- 9H5 · [3,5-bis(iodanyl)-2-oxidanyl-4-pyrrol-1-yl-phenyl]-(4-methylpiperazin-1-yl)methanone · in 2 records
- CA · Calcium ion · in 2 records
- EXN · [9-ethyl-7-(furan-2-yl)carbazol-3-yl]methyl-methyl-azanium · in 2 records
- EY2 · (7-bromanyl-9-ethyl-carbazol-3-yl)methyl-methyl-azanium · in 2 records
- EYB · [9-ethyl-7-(1,2-oxazol-4-yl)carbazol-3-yl]methyl-methyl-azanium · in 2 records
- EYE · [9-ethyl-7-(5-methylthiophen-2-yl)carbazol-3-yl]methyl-methyl-azanium · in 2 records
- SB · Antimony (III) ion · in 2 records
- 9GK · 3-iodanyl-2-oxidanyl-5-(2-phenylethoxy)-4-pyrrol-1-yl-benzoic acid · in 1 record
- 9GT · 3-iodanyl-2-oxidanyl-5-prop-2-enoxy-4-pyrrol-1-yl-benzoic acid · in 1 record
- 9GZ · 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid · in 1 record
- 9H2 · 6-(hydroxymethyl)-2,4-bis(iodanyl)-3-pyrrol-1-yl-phenol · in 1 record
- A1ARZ · 2-methyl-2-{5-[(3-{4-[(1-methylpiperidin-4-yl)amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl}prop-2-yn-1-yl)amino]pyridin-2-yl}propanenitrile · in 1 record
- A1IH3 · 5-iodanyl-2-methylsulfonyl-pyrimidine · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- CL · Chloride ion · in 1 record
- K · Potassium ion · in 1 record
Experiment against prediction
- 6T58 chain B against the predicted model P07355: TM-score 0.99, RMSD 0.92 Å
- 6T58 chain B against the predicted model P07355: TM-score 0.99, RMSD 0.92 Å
- 6T58 chain A against the predicted model P07355: TM-score 0.60, RMSD 1.28 Å
- 6T58 chain A against the predicted model P07355: TM-score 0.60, RMSD 1.28 Å
- 7EL4 chain A against the predicted model O15151: TM-score 0.87, RMSD 0.41 Å
- 5HP0 chain A against the predicted model P45481: TM-score 0.72, RMSD 1.55 Å
- 6LHD chain B against the predicted model Q07817: TM-score 0.41, RMSD 1.89 Å
- 6LHD chain A against the predicted model Q07817: TM-score 0.39, RMSD 2.65 Å
- 5HOU chain A against the predicted model P45481: TM-score 0.49, RMSD 3.34 Å
- 5HOU chain A against the predicted model P45481: TM-score 0.49, RMSD 3.34 Å
Elsewhere
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